Development of a physiologically-based pharmacokinetic model for ocular disposition of monoclonal

tuberculosistest
October 7, 2020 0 Comments

Tuning Monoclonal Antibody Galactosylation utilizing Raman Spectroscopy-Managed Lactic Acid Feeding

A key side of large-scale manufacturing of biotherapeutics is a well-designed and consistently-executed upstream cell tradition course of. Course of Analytical Know-how (PAT) instruments present enhanced monitoring and management capabilities to help constant course of execution, and still have potential to help in upkeep of product high quality at desired ranges.

One such device, Raman spectroscopy, has matured as a helpful method to realize real-time monitoring and management of key cell tradition course of attributes. We developed a Raman spectroscopy-based nutrient management technique to allow twin management of lactate and glucose ranges for a fed-batch CHO cell tradition course of for monoclonal antibody (mAb) manufacturing.

To attain this, PLS-based chemometric fashions for real-time prediction of glucose and lactate concentrations have been developed and deployed in suggestions management loops. Particularly, feeding of lactic acid post-metabolic shift was investigated primarily based on earlier work that has proven the impression of lactate ranges on ammonium in addition to mAb product high quality.

Three feeding methods have been assessed for impression on cell metabolism, productiveness, and product high quality: bolus-fed glucose, glucose management at four g/L, or simultaneous glucose management at four g/L and lactate management at 2 g/L. The third feeding technique resulted in a big discount in ammonium ranges (68%) whereas rising mAb galactosylation ranges by roughly 50%.

This work demonstrated that when deployed in a cell tradition course of, Raman spectroscopy is an efficient method for simultaneous management of a number of nutrient feeds, and that lactic acid feeding can have a optimistic impression on each cell metabolism and mAb product high quality. This text is protected by copyright. All rights reserved.

tuberculosistest
tuberculosistest

Mouse Paraoxonase 1 (PON1) ELISA Kit

DLR-PON1-Mu-96T 96T
EUR 635
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Paraoxonase 1 (PON1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Paraoxonase 1 (PON1) ELISA Kit

RDR-PON1-Mu-48Tests 48 Tests
EUR 511

Mouse Paraoxonase 1 (PON1) ELISA Kit

RDR-PON1-Mu-96Tests 96 Tests
EUR 709

Anti-PON1 Antibody (monoclonal, 9D3)

M00516 100ug/vial
EUR 334

Anti-PON1 Antibody (monoclonal, 6B1)

M00516-1 100ug/vial
EUR 334

Anti-PON1 Antibody (monoclonal, 11H2)

M00516-2 100ug/vial
EUR 294

Anti-PON1 Clone KRJ2 (100 µg)

0801014 100 µg
EUR 284
Description: Please contact Gentaur in order to receive the datasheet of the product.

Anti-PON1 Clone KRJ2 (1 mg)

0801097 1 mg
EUR 1689.04
Description: Please contact Gentaur in order to receive the datasheet of the product.

Rabbit Anti-Human PON1 Monoclonal Antibody

CABT-36017RH 100ug
EUR 840

anti-PON1

YF-PA24422 50 ul
EUR 334
Description: Mouse polyclonal to PON1

Mouse Monoclonal Anti-Mouse CD160 mAb, Biotin, (clone CNX46-3), (mouse IgG2bk)

MCD160-B 100 tests
EUR 469

Mouse Monoclonal Anti-Mouse CD160 mAb, FITC, (clone CNX46-3), (mouse IgG2bk)

MCD160-F 50 Tests
EUR 408

Mouse Monoclonal Anti-Mouse CD160 mAb, Purified, (clone CNX46-3), (mouse IgG2bk)

MCD160-M 100 ug
EUR 482

Mouse Monoclonal Anti-Mouse CD160 mAb, PE, (clone CNX46-3), (mouse IgG2bk)

MCD160-PE 50 tests
EUR 347

Human Paraoxonase 1 (PON1) ELISA Kit

RD-PON1-Hu-48Tests 48 Tests
EUR 478

Human Paraoxonase 1 (PON1) ELISA Kit

RD-PON1-Hu-96Tests 96 Tests
EUR 662

Rat Paraoxonase 1 (PON1) ELISA Kit

RD-PON1-Ra-48Tests 48 Tests
EUR 511

Rat Paraoxonase 1 (PON1) ELISA Kit

RD-PON1-Ra-96Tests 96 Tests
EUR 709

Human Paraoxonase 1 (PON1) ELISA Kit

DLR-PON1-Hu-48T 48T
EUR 479
Description: A sandwich quantitative ELISA assay kit for detection of Human Paraoxonase 1 (PON1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Paraoxonase 1 (PON1) ELISA Kit

DLR-PON1-Hu-96T 96T
EUR 621
Description: A sandwich quantitative ELISA assay kit for detection of Human Paraoxonase 1 (PON1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Paraoxonase 1 (PON1) ELISA Kit

DLR-PON1-Ra-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rat Paraoxonase 1 (PON1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Paraoxonase 1 (PON1) ELISA Kit

DLR-PON1-Ra-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rat Paraoxonase 1 (PON1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Paraoxonase 1 (PON1) ELISA Kit

RDR-PON1-Hu-48Tests 48 Tests
EUR 500

Human Paraoxonase 1 (PON1) ELISA Kit

RDR-PON1-Hu-96Tests 96 Tests
EUR 692

Rat Paraoxonase 1 (PON1) ELISA Kit

RDR-PON1-Ra-48Tests 48 Tests
EUR 534

Rat Paraoxonase 1 (PON1) ELISA Kit

RDR-PON1-Ra-96Tests 96 Tests
EUR 742

Anti-GFP (GF28R) Tag monoclonal antibody

ABP-MAB-GT007 100 ug Ask for price

PON1 recombinant monoclonal antibody

A5406 100ul X 3
EUR 595
Description: A recombinant monoclonal antibody from rabbit against human PON1 for WB, IHC,ELISA

Anti-?-Actin (BA3R) Loading Control Monoclonal Antibody

ABP-MAB-BL002 100 ug Ask for price

Anti-DYKDDDDK (FLAG) Tag (FG4R) Monoclonal Antibody

ABP-MAB-DT006 100 ug Ask for price

Anti-ERK1 (E32) Signal Transduction Monoclonal Antibody

ABP-MAB-ES001 100 ug Ask for price

Anti-ERK1 (E19) Signal Transduction Monoclonal Antibody

ABP-MAB-ES002 100 ug Ask for price

Anti-GAPDH (GA1R) Loading Control Monoclonal Antibody

ABP-MAB-GL001 100 ug Ask for price

Anti-GST Tag (GST.B6 / G2R) Monoclonal Antibody

ABP-MAB-GT003 100 ug Ask for price

Anti-His Tag (HIS.H8 / EH158) Monoclonal Antibody

ABP-MAB-HT001 100 ug Ask for price

Anti-HA Tag (HA.C5 / C10) Monoclonal Antibody

ABP-MAB-HT002 100 ug Ask for price

Anti-Myc Tag (Myc.A7 / M19) Monoclonal Antibody

ABP-MAB-MT005 100 ug Ask for price

Anti-V5 Tag (E10 / V4RR) Monoclonal Antibody

ABP-MAB-VT004 100 ug Ask for price

Monoclonal Functional BAFF-R (mouse) Antibody, mAb , Clone: 9B9

APR16043G 0.1mg
EUR 528
Description: A Monoclonal antibody against Human Functional BAFF-R (mouse), mAb . The antibodies are raised in Purified From Concentrated Hybridoma Tissue Culture Supernatant. and are from clone 9B9. This antibody is applicable in FC

Anti-PON1 Antibody

PA2253 100ug/vial
EUR 294

Anti-PON1 antibody

STJ25055 100 µl
EUR 277
Description: The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.

Anti-PON1 antibody

STJ25056 100 µl
EUR 277
Description: The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.

Anti-PON1 antibody

STJ29477 100 µl
EUR 277
Description: The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.

Anti-PON1 Antibody

A00516 100ug/vial
EUR 334

Anti-PON1 Antibody

A00516-1 100ug/vial
EUR 294

Anti-PON1 Antibody

A00516-3 100ug/vial
EUR 334

Anti-PON1 antibody

STJ98804 200 µl
EUR 197
Description: Rabbit polyclonal to PON1.

anti- PON1 antibody

FNab06638 100µg
EUR 505.25
Description: Antibody raised against PON1

Anti-PON1 antibody

PAab06638 100 ug
EUR 355

Anti-PON1 (2H7)

YF-MA14808 100 ug
EUR 363
Description: Mouse monoclonal to PON1

Anti-ERK1/2 (E31R) Signal Transduction Monoclonal Antibody

ABP-MAB-ES003 100 ug Ask for price

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-RFP (Red Fluorescent Protein) Tag (RF5R) Monoclonal Antibody

ABP-MAB-RT008 100 ug Ask for price

Anti-PON1 Biotinylated Antibody

A00516-Biotin 50ug/vial
EUR 294

Magic™ Anti-IBV Mab, Clone N53242

DCABY-4536 1 mg
EUR 754

Magic™ Anti-IBV Mab, Clone N23323

DCABY-4539 1 mg
EUR 754

Mouse Anti-Omethoate monoclonal antibody, clone OMO

HMABPY0001-100ug 100 ug
EUR 533

Mouse Anti-Omethoate monoclonal antibody, clone OMO

HMABPY0001-1mg 1 mg
EUR 1313

Mouse Anti-Metalaxyl monoclonal antibody, clone MA

HMABPY0003-100ug 100 ug
EUR 533

Mouse Anti-Metalaxyl monoclonal antibody, clone MA

HMABPY0003-1mg 1 mg
EUR 1313

Mouse Anti-Fluoroquinolones monoclonal antibody, clone FK1

HMABPY082-100ug 100 ug
EUR 533

Mouse Anti-Fluoroquinolones monoclonal antibody, clone FK1

HMABPY082-1mg 1 mg
EUR 1313

Mouse Anti-Ovalbumin monoclonal antibody, clone OVAD

HMABPY118D-100ug 100 ug
EUR 533

Mouse Anti-Ovalbumin monoclonal antibody, clone OVAD

HMABPY118D-1mg 1 mg
EUR 1313

Mouse Anti-PNA monoclonal antibody, clone PNAD

HMABPY119D-100ug 100 ug
EUR 533

Mouse Anti-PNA monoclonal antibody, clone PNAD

HMABPY119D-1mg 1 mg
EUR 1313

Mouse Anti-Casein monoclonal antibody, clone CSD

HMABPY120D-100ug 100 ug
EUR 533

Mouse Anti-Casein monoclonal antibody, clone CSD

HMABPY120D-1mg 1 mg
EUR 1313

Mouse Anti-Sulfonamides monoclonal antibody, clone SF2

DMAB8840-100ug 100 ug
EUR 533

Mouse Anti-Sulfonamides monoclonal antibody, clone SF2

DMAB8840-1mg 1 mg
EUR 1313

Mouse Anti-Sulfonamides monoclonal antibody, clone SF1

DMAB88404M-100ug 100 ug
EUR 533

Mouse Anti-Sulfonamides monoclonal antibody, clone SF1

DMAB88404M-1mg 1 mg
EUR 1313

Mouse Anti-TGEV monoclonal antibody, clone 322.65

DMABT-Z60015 1 mg
EUR 819

Mouse Anti-Albendazole monoclonal antibody, clone ABZ2

CABT-L3042-100ug 100 ug
EUR 533

Mouse Anti-Albendazole monoclonal antibody, clone ABZ2

CABT-L3042-1mg 1 mg
EUR 1313

Mouse Anti-Fluoroquinolones monoclonal antibody, clone FK2

CABT-L3046-100ug 100 ug
EUR 533

Mouse Anti-Fluoroquinolones monoclonal antibody, clone FK2

CABT-L3046-1mg 1 mg
EUR 1313

Mouse Anti-Fluoroquinolones monoclonal antibody, clone FK3

CABT-L3047-100ug 100 ug
EUR 533

Mouse Anti-Fluoroquinolones monoclonal antibody, clone FK3

CABT-L3047-1mg 1 mg
EUR 1313

Mouse Anti-Cyproheptadine monoclonal antibody, clone CHD

CABT-L3052-100ug 100 ug
EUR 533

Mouse Anti-Cyproheptadine monoclonal antibody, clone CHD

CABT-L3052-1mg 1 mg
EUR 1313

Mouse Anti-Clonidine monoclonal antibody, clone CLD

CABT-L3053-100ug 100 ug
EUR 533

Mouse Anti-Clonidine monoclonal antibody, clone CLD

CABT-L3053-1mg 1 mg
EUR 1313

Mouse Anti-Diaveridine monoclonal antibody, clone DVD

CABT-L3055-100ug 100 ug
EUR 533

Mouse Anti-Diaveridine monoclonal antibody, clone DVD

CABT-L3055-1mg 1 mg
EUR 1313

Mouse Anti-Ormetoprim monoclonal antibody, clone OMP

CABT-L3056-100ug 100 ug
EUR 533

Mouse Anti-Ormetoprim monoclonal antibody, clone OMP

CABT-L3056-1mg 1 mg
EUR 1313

Mouse Anti-Clindamycin monoclonal antibody, clone CDM

CABT-L3057-100ug 100 ug
EUR 533

Mouse Anti-Clindamycin monoclonal antibody, clone CDM

CABT-L3057-1mg 1 mg
EUR 1313

Mouse Anti-Azithromycin monoclonal antibody, clone ATM

CABT-L3058-100ug 100 ug
EUR 533

Mouse Anti-Azithromycin monoclonal antibody, clone ATM

CABT-L3058-1mg 1 mg
EUR 1313

Mouse Anti-Roxithromycin monoclonal antibody, clone RTM

CABT-L3059-100ug 100 ug
EUR 533

Mouse Anti-Roxithromycin monoclonal antibody, clone RTM

CABT-L3059-1mg 1 mg
EUR 1313

Mouse Anti-Clarithromycin monoclonal antibody, clone CTM

CABT-L3060-100ug 100 ug
EUR 533

Mouse Anti-Clarithromycin monoclonal antibody, clone CTM

CABT-L3060-1mg 1 mg
EUR 1313

Mouse Anti-Spiramycin monoclonal antibody, clone SPM

CABT-L3062-100ug 100 ug
EUR 533

Mouse Anti-Spiramycin monoclonal antibody, clone SPM

CABT-L3062-1mg 1 mg
EUR 1313

Mouse Anti-Kitasamycin monoclonal antibody, clone KSM

CABT-L3063-100ug 100 ug
EUR 533

Mouse Anti-Kitasamycin monoclonal antibody, clone KSM

CABT-L3063-1mg 1 mg
EUR 1313

Mouse Anti-Halofuginone monoclonal antibody, clone HAL

CABT-L3065-100ug 100 ug
EUR 533

Mouse Anti-Halofuginone monoclonal antibody, clone HAL

CABT-L3065-1mg 1 mg
EUR 1313

Mouse Anti-Aminophylline monoclonal antibody, clone APL

CABT-L3066-100ug 100 ug
EUR 533

Mouse Anti-Aminophylline monoclonal antibody, clone APL

CABT-L3066-1mg 1 mg
EUR 1313

Mouse Anti-Tiamulin monoclonal antibody, clone TML

CABT-L3067-100ug 100 ug
EUR 533

Mouse Anti-Tiamulin monoclonal antibody, clone TML

CABT-L3067-1mg 1 mg
EUR 1313

Mouse Anti-Flavomycin monoclonal antibody, clone FVM

CABT-L3068-100ug 100 ug
EUR 533

Mouse Anti-Flavomycin monoclonal antibody, clone FVM

CABT-L3068-1mg 1 mg
EUR 1313

Mouse Anti-Furanacrylate monoclonal antibody, clone FAA

CABT-L3069-100ug 100 ug
EUR 533

Mouse Anti-Furanacrylate monoclonal antibody, clone FAA

CABT-L3069-1mg 1 mg
EUR 1313

Mouse Anti-Thiamethoxam monoclonal antibody, clone TMO

CABT-L3071-100ug 100 ug
EUR 533

Mouse Anti-Thiamethoxam monoclonal antibody, clone TMO

CABT-L3071-1mg 1 mg
EUR 1313

Mouse Anti-Nifursol monoclonal antibody, clone NFS

CABT-L3079-100ug 100 ug
EUR 533

Mouse Anti-Nifursol monoclonal antibody, clone NFS

CABT-L3079-1mg 1 mg
EUR 1313

Mouse Anti-Azaperone monoclonal antibody, clone AZP

CABT-L3081-100ug 100 ug
EUR 533

Mouse Anti-Azaperone monoclonal antibody, clone AZP

CABT-L3081-1mg 1 mg
EUR 1313

Mouse Anti-Chlorpromazine monoclonal antibody, clone CPZ

CABT-L3082-100ug 100 ug
EUR 533

Mouse Anti-Chlorpromazine monoclonal antibody, clone CPZ

CABT-L3082-1mg 1 mg
EUR 1313

Mouse Anti-Procaine monoclonal antibody, clone PRC

CABT-L3083-100ug 100 ug
EUR 533

Mouse Anti-Procaine monoclonal antibody, clone PRC

CABT-L3083-1mg 1 mg
EUR 1313

Mouse Anti-Meloxicam monoclonal antibody, clone MLX

CABT-L3084-100ug 100 ug
EUR 533

Structural and practical characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 operate by way of a novel non-competitive mechanism of motion

 

  • Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 inside particular tumor microenvironments generates an immunosuppressive area of interest that successfully renders the tumor ‘invisible’ to the host’s immune system.

 

  • Elevated ARG2 expression results in a concomitant depletion of native L-arginine ranges, which in flip results in suppression of anti-tumor T-cell-mediated immune responses. Right here we describe the isolation and characterization of a excessive affinity antibody (C0021158) that inhibits ARG2 enzymatic operate fully, successfully restoring T-cell proliferation in vitro. Enzyme kinetic research confirmed that C0021158 reveals a noncompetitive mechanism of motion, inhibiting ARG2 independently of L-arginine concentrations.

 

  • To elucidate C0021158’s inhibitory mechanism at a structural degree, the co-crystal construction of the Fab in advanced with trimeric ARG2 was solved. C0021158’s epitope was consequently mapped to an space a ways from the enzyme’s substrate binding cleft, indicating an allosteric mechanism was being employed. Following C0021158 binding, distinct areas of ARG2 endure main conformational modifications.

 

  • Notably, the spine construction of a surface-exposed loop is totally rearranged, resulting in the formation of a brand new brief helix construction on the Fab-ARG2 interface. Furthermore, this large-scale structural transforming at ARG2’s epitope interprets into extra delicate modifications throughout the enzyme’s lively website. An arginine residue at place 39 is reoriented inwards, sterically impeding the binding of L-arginine. Arg39 can be predicted to change the pOkA of a key catalytic histidine residue at place 160, additional attenuating ARG2’s enzymatic operate.

 

  • In silicomolecular docking simulations predict that L-arginine is unable to bind successfully when antibody is certain, a prediction supported by isothermal calorimetry experiments utilizing an L-arginine mimetic. Particularly, focusing on ARG2 within the tumor microenvironment via the appliance of C0021158, doubtlessly together with normal chemotherapy regimens or alternate immunotherapies, represents a possible new technique to focus on immune chilly tumors.

Growth of a physiologically-based pharmacokinetic mannequin for ocular disposition of monoclonal antibodies in rabbits

 

  • Growth of protein therapeutics for ocular problems, notably age-related macular degeneration (AMD), is a extremely aggressive and increasing therapeutic space. Nevertheless, the appliance of a predictive and translatable ocular PK mannequin to better perceive ocular disposition of protein therapeutics, reminiscent of a physiologically-based pharmacokinetic (PBPK) mannequin, is lacking from the literature. Right here, we current an growth of an antibody platform PBPK mannequin in the direction of rabbit and incorporate a novel anatomical and physiologically related ocular part.

 

  • Parameters describing all tissues, flows, and binding occasions have been obtained from present literature and glued a priori. First, translation of the platform PBPK mannequin to rabbit was confirmed by evaluating the mannequin’s capability to foretell plasma PK of a systemically administered exogenous antibody.

 

  • Then, the PBPK mannequin with the brand new ocular part was validated by estimation of serum and ocular (i.e. aqueous humor, retina, and vitreous humor) PK of two intravitreally administered monoclonal antibodies. We present that the proposed PBPK mannequin is able to precisely (i.e. inside twofold) predicting ocular publicity of antibody-based medication. The proposed PBPK mannequin can be utilized for preclinical-to-clinical translation of antibodies developed for ocular problems, and evaluation of ocular toxicity for systemically administered antibody-based therapeutics.

 

Mouse Paraoxonase 1 (PON1) ELISA Kit

RDR-PON1-Mu-96Tests 96 Tests
EUR 709

Anti-PON1 Antibody (monoclonal, 9D3)

M00516 100ug/vial
EUR 334

Anti-PON1 Antibody (monoclonal, 6B1)

M00516-1 100ug/vial
EUR 334

Anti-PON1 Antibody (monoclonal, 11H2)

M00516-2 100ug/vial
EUR 294

Anti-PON1 Clone KRJ1 (100 µg)

0801012 100 µg
EUR 284
Description: Please contact Gentaur in order to receive the datasheet of the product.

Anti-PON1 Clone KRJ1 (1 mg)

0801095 1 mg
EUR 1689.04
Description: Please contact Gentaur in order to receive the datasheet of the product.

Rabbit Anti-Human PON1 Monoclonal Antibody

CABT-36017RH 100ug
EUR 840

anti-PON1

YF-PA24422 50 ul
EUR 334
Description: Mouse polyclonal to PON1

Mouse Monoclonal Anti-Mouse CD160 mAb, Biotin, (clone CNX46-3), (mouse IgG2bk)

MCD160-B 100 tests
EUR 469

Mouse Monoclonal Anti-Mouse CD160 mAb, FITC, (clone CNX46-3), (mouse IgG2bk)

MCD160-F 50 Tests
EUR 408

Mouse Monoclonal Anti-Mouse CD160 mAb, Purified, (clone CNX46-3), (mouse IgG2bk)

MCD160-M 100 ug
EUR 482

Mouse Monoclonal Anti-Mouse CD160 mAb, PE, (clone CNX46-3), (mouse IgG2bk)

MCD160-PE 50 tests
EUR 347

Human Paraoxonase 1 (PON1) ELISA Kit

RD-PON1-Hu-48Tests 48 Tests
EUR 478

Human Paraoxonase 1 (PON1) ELISA Kit

RD-PON1-Hu-96Tests 96 Tests
EUR 662

Rat Paraoxonase 1 (PON1) ELISA Kit

RD-PON1-Ra-48Tests 48 Tests
EUR 511

Rat Paraoxonase 1 (PON1) ELISA Kit

RD-PON1-Ra-96Tests 96 Tests
EUR 709

Human Paraoxonase 1 (PON1) ELISA Kit

DLR-PON1-Hu-48T 48T
EUR 479
Description: A sandwich quantitative ELISA assay kit for detection of Human Paraoxonase 1 (PON1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Paraoxonase 1 (PON1) ELISA Kit

DLR-PON1-Hu-96T 96T
EUR 621
Description: A sandwich quantitative ELISA assay kit for detection of Human Paraoxonase 1 (PON1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Paraoxonase 1 (PON1) ELISA Kit

DLR-PON1-Ra-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rat Paraoxonase 1 (PON1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Paraoxonase 1 (PON1) ELISA Kit

DLR-PON1-Ra-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rat Paraoxonase 1 (PON1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Paraoxonase 1 (PON1) ELISA Kit

RDR-PON1-Hu-48Tests 48 Tests
EUR 500

Human Paraoxonase 1 (PON1) ELISA Kit

RDR-PON1-Hu-96Tests 96 Tests
EUR 692

Rat Paraoxonase 1 (PON1) ELISA Kit

RDR-PON1-Ra-48Tests 48 Tests
EUR 534

Rat Paraoxonase 1 (PON1) ELISA Kit

RDR-PON1-Ra-96Tests 96 Tests
EUR 742

Anti-GFP (GF28R) Tag monoclonal antibody

ABP-MAB-GT007 100 ug Ask for price

PON1 recombinant monoclonal antibody

A5406 100ul X 3
EUR 595
Description: A recombinant monoclonal antibody from rabbit against human PON1 for WB, IHC,ELISA

Anti-?-Actin (BA3R) Loading Control Monoclonal Antibody

ABP-MAB-BL002 100 ug Ask for price

Anti-DYKDDDDK (FLAG) Tag (FG4R) Monoclonal Antibody

ABP-MAB-DT006 100 ug Ask for price

Anti-ERK1 (E32) Signal Transduction Monoclonal Antibody

ABP-MAB-ES001 100 ug Ask for price

Anti-ERK1 (E19) Signal Transduction Monoclonal Antibody

ABP-MAB-ES002 100 ug Ask for price

Anti-GAPDH (GA1R) Loading Control Monoclonal Antibody

ABP-MAB-GL001 100 ug Ask for price

Anti-GST Tag (GST.B6 / G2R) Monoclonal Antibody

ABP-MAB-GT003 100 ug Ask for price

Anti-His Tag (HIS.H8 / EH158) Monoclonal Antibody

ABP-MAB-HT001 100 ug Ask for price

Anti-HA Tag (HA.C5 / C10) Monoclonal Antibody

ABP-MAB-HT002 100 ug Ask for price

Anti-Myc Tag (Myc.A7 / M19) Monoclonal Antibody

ABP-MAB-MT005 100 ug Ask for price

Anti-V5 Tag (E10 / V4RR) Monoclonal Antibody

ABP-MAB-VT004 100 ug Ask for price

Monoclonal Functional BAFF-R (mouse) Antibody, mAb , Clone: 9B9

APR16043G 0.1mg
EUR 528
Description: A Monoclonal antibody against Human Functional BAFF-R (mouse), mAb . The antibodies are raised in Purified From Concentrated Hybridoma Tissue Culture Supernatant. and are from clone 9B9. This antibody is applicable in FC

Anti-PON1 Antibody

PA2253 100ug/vial
EUR 294

Anti-PON1 antibody

STJ25055 100 µl
EUR 277
Description: The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.

Anti-PON1 antibody

STJ25056 100 µl
EUR 277
Description: The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.

Anti-PON1 antibody

STJ29477 100 µl
EUR 277
Description: The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.

Anti-PON1 Antibody

A00516 100ug/vial
EUR 334

Anti-PON1 Antibody

A00516-1 100ug/vial
EUR 294

Anti-PON1 Antibody

A00516-3 100ug/vial
EUR 334

Anti-PON1 antibody

STJ98804 200 µl
EUR 197
Description: Rabbit polyclonal to PON1.

anti- PON1 antibody

FNab06638 100µg
EUR 505.25
Description: Antibody raised against PON1

Anti-PON1 antibody

PAab06638 100 ug
EUR 355

Anti-PON1 (2H7)

YF-MA14808 100 ug
EUR 363
Description: Mouse monoclonal to PON1

Anti-ERK1/2 (E31R) Signal Transduction Monoclonal Antibody

ABP-MAB-ES003 100 ug Ask for price

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-RFP (Red Fluorescent Protein) Tag (RF5R) Monoclonal Antibody

ABP-MAB-RT008 100 ug Ask for price

Anti-PON1 Biotinylated Antibody

A00516-Biotin 50ug/vial
EUR 294

Magic™ Anti-IBV Mab, Clone N53242

DCABY-4536 1 mg
EUR 754

Magic™ Anti-IBV Mab, Clone N23323

DCABY-4539 1 mg
EUR 754

Mouse Anti-Omethoate monoclonal antibody, clone OMO

HMABPY0001-100ug 100 ug
EUR 533

Mouse Anti-Omethoate monoclonal antibody, clone OMO

HMABPY0001-1mg 1 mg
EUR 1313

Mouse Anti-Metalaxyl monoclonal antibody, clone MA

HMABPY0003-100ug 100 ug
EUR 533

Mouse Anti-Metalaxyl monoclonal antibody, clone MA

HMABPY0003-1mg 1 mg
EUR 1313

Mouse Anti-Fluoroquinolones monoclonal antibody, clone FK1

HMABPY082-100ug 100 ug
EUR 533

Mouse Anti-Fluoroquinolones monoclonal antibody, clone FK1

HMABPY082-1mg 1 mg
EUR 1313

Mouse Anti-Ovalbumin monoclonal antibody, clone OVAD

HMABPY118D-100ug 100 ug
EUR 533

Mouse Anti-Ovalbumin monoclonal antibody, clone OVAD

HMABPY118D-1mg 1 mg
EUR 1313

Mouse Anti-PNA monoclonal antibody, clone PNAD

HMABPY119D-100ug 100 ug
EUR 533

Mouse Anti-PNA monoclonal antibody, clone PNAD

HMABPY119D-1mg 1 mg
EUR 1313

Mouse Anti-Casein monoclonal antibody, clone CSD

HMABPY120D-100ug 100 ug
EUR 533

Mouse Anti-Casein monoclonal antibody, clone CSD

HMABPY120D-1mg 1 mg
EUR 1313

Mouse Anti-Sulfonamides monoclonal antibody, clone SF2

DMAB8840-100ug 100 ug
EUR 533

Mouse Anti-Sulfonamides monoclonal antibody, clone SF2

DMAB8840-1mg 1 mg
EUR 1313

Mouse Anti-Sulfonamides monoclonal antibody, clone SF1

DMAB88404M-100ug 100 ug
EUR 533

Mouse Anti-Sulfonamides monoclonal antibody, clone SF1

DMAB88404M-1mg 1 mg
EUR 1313

Mouse Anti-TGEV monoclonal antibody, clone 322.65

DMABT-Z60015 1 mg
EUR 819

Mouse Anti-Albendazole monoclonal antibody, clone ABZ2

CABT-L3042-100ug 100 ug
EUR 533

Mouse Anti-Albendazole monoclonal antibody, clone ABZ2

CABT-L3042-1mg 1 mg
EUR 1313

Mouse Anti-Fluoroquinolones monoclonal antibody, clone FK2

CABT-L3046-100ug 100 ug
EUR 533

Mouse Anti-Fluoroquinolones monoclonal antibody, clone FK2

CABT-L3046-1mg 1 mg
EUR 1313

Mouse Anti-Fluoroquinolones monoclonal antibody, clone FK3

CABT-L3047-100ug 100 ug
EUR 533

Mouse Anti-Fluoroquinolones monoclonal antibody, clone FK3

CABT-L3047-1mg 1 mg
EUR 1313

Mouse Anti-Cyproheptadine monoclonal antibody, clone CHD

CABT-L3052-100ug 100 ug
EUR 533

Mouse Anti-Cyproheptadine monoclonal antibody, clone CHD

CABT-L3052-1mg 1 mg
EUR 1313

Mouse Anti-Clonidine monoclonal antibody, clone CLD

CABT-L3053-100ug 100 ug
EUR 533

Mouse Anti-Clonidine monoclonal antibody, clone CLD

CABT-L3053-1mg 1 mg
EUR 1313

Mouse Anti-Diaveridine monoclonal antibody, clone DVD

CABT-L3055-100ug 100 ug
EUR 533

Mouse Anti-Diaveridine monoclonal antibody, clone DVD

CABT-L3055-1mg 1 mg
EUR 1313

Mouse Anti-Ormetoprim monoclonal antibody, clone OMP

CABT-L3056-100ug 100 ug
EUR 533

Mouse Anti-Ormetoprim monoclonal antibody, clone OMP

CABT-L3056-1mg 1 mg
EUR 1313

Mouse Anti-Clindamycin monoclonal antibody, clone CDM

CABT-L3057-100ug 100 ug
EUR 533

Mouse Anti-Clindamycin monoclonal antibody, clone CDM

CABT-L3057-1mg 1 mg
EUR 1313

Mouse Anti-Azithromycin monoclonal antibody, clone ATM

CABT-L3058-100ug 100 ug
EUR 533

Mouse Anti-Azithromycin monoclonal antibody, clone ATM

CABT-L3058-1mg 1 mg
EUR 1313

Mouse Anti-Roxithromycin monoclonal antibody, clone RTM

CABT-L3059-100ug 100 ug
EUR 533

Mouse Anti-Roxithromycin monoclonal antibody, clone RTM

CABT-L3059-1mg 1 mg
EUR 1313

Mouse Anti-Clarithromycin monoclonal antibody, clone CTM

CABT-L3060-100ug 100 ug
EUR 533

Mouse Anti-Clarithromycin monoclonal antibody, clone CTM

CABT-L3060-1mg 1 mg
EUR 1313

Mouse Anti-Spiramycin monoclonal antibody, clone SPM

CABT-L3062-100ug 100 ug
EUR 533

Mouse Anti-Spiramycin monoclonal antibody, clone SPM

CABT-L3062-1mg 1 mg
EUR 1313

Mouse Anti-Kitasamycin monoclonal antibody, clone KSM

CABT-L3063-100ug 100 ug
EUR 533

Mouse Anti-Kitasamycin monoclonal antibody, clone KSM

CABT-L3063-1mg 1 mg
EUR 1313

Mouse Anti-Halofuginone monoclonal antibody, clone HAL

CABT-L3065-100ug 100 ug
EUR 533

Mouse Anti-Halofuginone monoclonal antibody, clone HAL

CABT-L3065-1mg 1 mg
EUR 1313

Mouse Anti-Aminophylline monoclonal antibody, clone APL

CABT-L3066-100ug 100 ug
EUR 533

Mouse Anti-Aminophylline monoclonal antibody, clone APL

CABT-L3066-1mg 1 mg
EUR 1313

Mouse Anti-Tiamulin monoclonal antibody, clone TML

CABT-L3067-100ug 100 ug
EUR 533

Mouse Anti-Tiamulin monoclonal antibody, clone TML

CABT-L3067-1mg 1 mg
EUR 1313

Mouse Anti-Flavomycin monoclonal antibody, clone FVM

CABT-L3068-100ug 100 ug
EUR 533

Mouse Anti-Flavomycin monoclonal antibody, clone FVM

CABT-L3068-1mg 1 mg
EUR 1313

Mouse Anti-Furanacrylate monoclonal antibody, clone FAA

CABT-L3069-100ug 100 ug
EUR 533

Mouse Anti-Furanacrylate monoclonal antibody, clone FAA

CABT-L3069-1mg 1 mg
EUR 1313

Mouse Anti-Thiamethoxam monoclonal antibody, clone TMO

CABT-L3071-100ug 100 ug
EUR 533

Mouse Anti-Thiamethoxam monoclonal antibody, clone TMO

CABT-L3071-1mg 1 mg
EUR 1313

Mouse Anti-Nifursol monoclonal antibody, clone NFS

CABT-L3079-100ug 100 ug
EUR 533

Mouse Anti-Nifursol monoclonal antibody, clone NFS

CABT-L3079-1mg 1 mg
EUR 1313

Mouse Anti-Azaperone monoclonal antibody, clone AZP

CABT-L3081-100ug 100 ug
EUR 533

Mouse Anti-Azaperone monoclonal antibody, clone AZP

CABT-L3081-1mg 1 mg
EUR 1313

Mouse Anti-Chlorpromazine monoclonal antibody, clone CPZ

CABT-L3082-100ug 100 ug
EUR 533

Mouse Anti-Chlorpromazine monoclonal antibody, clone CPZ

CABT-L3082-1mg 1 mg
EUR 1313

Mouse Anti-Procaine monoclonal antibody, clone PRC

CABT-L3083-100ug 100 ug
EUR 533

Mouse Anti-Procaine monoclonal antibody, clone PRC

CABT-L3083-1mg 1 mg
EUR 1313

Mouse Anti-Meloxicam monoclonal antibody, clone MLX

CABT-L3084-100ug 100 ug
EUR 533

Mouse Anti-Meloxicam monoclonal antibody, clone MLX

CABT-L3084-1mg 1 mg
EUR 1313

Mouse Anti-Tadalafil monoclonal antibody, clone TD

CABT-L3085-100ug 100 ug
EUR 533

Mouse Anti-Tadalafil monoclonal antibody, clone TD

CABT-L3085-1mg 1 mg
EUR 1313

Mouse Anti-Benzopyrene monoclonal antibody, clone BaP

CABT-L3086-100ug 100 ug
EUR 533

Mouse Anti-Benzopyrene monoclonal antibody, clone BaP

CABT-L3086-1mg 1 mg
EUR 1313

Mouse Anti-Capsaicin monoclonal antibody, clone CPS

CABT-L3087-100ug 100 ug
EUR 533

Mouse Anti-Capsaicin monoclonal antibody, clone CPS

CABT-L3087-1mg 1 mg
EUR 1313

Mouse Anti-Cimaterol monoclonal antibody, clone CIM

CABT-L3088-100ug 100 ug
EUR 533

Mouse Anti-Cimaterol monoclonal antibody, clone CIM

CABT-L3088-1mg 1 mg
EUR 1313

Mouse Anti-Tetrodotoxin monoclonal antibody, clone TTX

CABT-L3089-100ug 100 ug
EUR 533

Mouse Anti-Tetrodotoxin monoclonal antibody, clone TTX

CABT-L3089-1mg 1 mg
EUR 1313

Mouse Anti-Clothianidin monoclonal antibody, clone CTD

CABT-L3091-100ug 100 ug
EUR 533

Mouse Anti-Clothianidin monoclonal antibody, clone CTD

CABT-L3091-1mg 1 mg
EUR 1313

Mouse Anti-Sibutramine monoclonal antibody, clone SBTM

CABT-L3093-100ug 100 ug
EUR 533

Mouse Anti-Sibutramine monoclonal antibody, clone SBTM

CABT-L3093-1mg 1 mg
EUR 1313

Mouse Anti-Indometacin monoclonal antibody, clone IDM

CABT-L3094-100ug 100 ug
EUR 533

Mouse Anti-Indometacin monoclonal antibody, clone IDM

CABT-L3094-1mg 1 mg
EUR 1313

Mouse Anti-Berberine monoclonal antibody, clone BBR

CABT-L3096-100ug 100 ug
EUR 533

Mouse Anti-Berberine monoclonal antibody, clone BBR

CABT-L3096-1mg 1 mg
EUR 1313

Mouse Anti-Calicheamicin monoclonal antibody, clone C2H0

CABT-L3107 100 uL
EUR 1937

Mouse Anti-Duocarmycin monoclonal antibody, clone  F22B2

CABT-L3109 100 uL
EUR 1646

Mouse Anti-Amanitin monoclonal antibody, clone I4F2

CABT-L3113 100 uL
EUR 1937

Mouse Anti-SN38 monoclonal antibody, clone 20G22B0E7

CABT-L3115 100 uL
EUR 1646

Mouse Anti-ADV monoclonal antibody, clone 23H07

CABT-L3195 1 mg
EUR 819

Mouse Anti-ICHV monoclonal antibody, clone B21E25

CABT-L3197 1 mg
EUR 819

Mouse Anti-MH monoclonal antibody, clone 9C24

CABT-L3198 1 mg
EUR 819

Mouse Anti-CCV monoclonal antibody, clone B83,4

CABT-L3199 1 mg
EUR 819

Mouse Anti-Dioxin monoclonal antibody, clone DXN

CABT-L4232-100ug 100 ug
EUR 533

Mouse Anti-Dioxin monoclonal antibody, clone DXN

CABT-L4232-1mg 1 mg
EUR 1313

Mouse Anti-Amantadine monoclonal antibody, clone AM

CABT-L4233-100ug 100 ug
EUR 533

Mouse Anti-Amantadine monoclonal antibody, clone AM

CABT-L4233-1mg 1 mg
EUR 1313

Mouse Anti-Aminobenzimidazole monoclonal antibody, clone ABI

CABT-L4235-100ug 100 ug
EUR 533

Mouse Anti-Aminobenzimidazole monoclonal antibody, clone ABI

CABT-L4235-1mg 1 mg
EUR 1313

Mouse Anti-Carbadox monoclonal antibody, clone CBD

CABT-L4236-100ug 100 ug
EUR 533

Mouse Anti-Carbadox monoclonal antibody, clone CBD

CABT-L4236-1mg 1 mg
EUR 1313

Mouse Anti-Rifampicin monoclonal antibody, clone RFP

CABT-L4237-100ug 100 ug
EUR 533

Mouse Anti-Rifampicin monoclonal antibody, clone RFP

CABT-L4237-1mg 1 mg
EUR 1313

Mouse Anti-Praziquantel monoclonal antibody, clone PZQ

CABT-L4238-100ug 100 ug
EUR 533

Mouse Anti-Praziquantel monoclonal antibody, clone PZQ

CABT-L4238-1mg 1 mg
EUR 1313

Mouse Anti-Robenidine monoclonal antibody, clone RBD

CABT-L4239-100ug 100 ug
EUR 533

Mouse Anti-Robenidine monoclonal antibody, clone RBD

CABT-L4239-1mg 1 mg
EUR 1313

Mouse Anti-Dinitolmide monoclonal antibody, clone DNT

CABT-L4240-100ug 100 ug
EUR 533

Mouse Anti-Dinitolmide monoclonal antibody, clone DNT

CABT-L4240-1mg 1 mg
EUR 1313

Mouse Anti-Ethopabate monoclonal antibody, clone EPB

CABT-L4241-100ug 100 ug
EUR 533

Mouse Anti-Ethopabate monoclonal antibody, clone EPB

CABT-L4241-1mg 1 mg
EUR 1313

Mouse Anti-Imidocarb monoclonal antibody, clone IMC

CABT-L4243-100ug 100 ug
EUR 533

Mouse Anti-Imidocarb monoclonal antibody, clone IMC

CABT-L4243-1mg 1 mg
EUR 1313

Mouse Anti-Triazophos monoclonal antibody, clone TZP

CABT-L4244-100ug 100 ug
EUR 533

Mouse Anti-Triazophos monoclonal antibody, clone TZP

CABT-L4244-1mg 1 mg
EUR 1313

Mouse Anti-Isoprocarb monoclonal antibody, clone IPC

CABT-L4245-100ug 100 ug
EUR 533

Mouse Anti-Isoprocarb monoclonal antibody, clone IPC

CABT-L4245-1mg 1 mg
EUR 1313

Mouse Anti-Pyrimethanil monoclonal antibody, clone PMT

CABT-L4246-100ug 100 ug
EUR 533

Mouse Anti-Pyrimethanil monoclonal antibody, clone PMT

CABT-L4246-1mg 1 mg
EUR 1313

Mouse Anti-Picoxystrobin monoclonal antibody, clone POS

CABT-L4247-100ug 100 ug
EUR 533

Mouse Anti-Picoxystrobin monoclonal antibody, clone POS

CABT-L4247-1mg 1 mg
EUR 1313

Mouse Anti-Carbamazepine monoclonal antibody, clone CMZ

CABT-L4248-100ug 100 ug
EUR 533

Mouse Anti-Carbamazepine monoclonal antibody, clone CMZ

CABT-L4248-1mg 1 mg
EUR 1313

Mouse Anti-Carazolol monoclonal antibody, clone CZL

CABT-L4249-100ug 100 ug
EUR 533

Mouse Anti-Carazolol monoclonal antibody, clone CZL

CABT-L4249-1mg 1 mg
EUR 1313

Mouse Anti-Glibenclamide monoclonal antibody, clone GBC

CABT-L4250-100ug 100 ug
EUR 533

Mouse Anti-Glibenclamide monoclonal antibody, clone GBC

CABT-L4250-1mg 1 mg
EUR 1313

Mouse Anti-Metformin monoclonal antibody, clone MF

CABT-L4251-100ug 100 ug
EUR 533

Mouse Anti-Metformin monoclonal antibody, clone MF

CABT-L4251-1mg 1 mg
EUR 1313

Mouse Anti-Diclofenac monoclonal antibody, clone DC

CABT-L4252-100ug 100 ug
EUR 533

Mouse Anti-Diclofenac monoclonal antibody, clone DC

CABT-L4252-1mg 1 mg
EUR 1313

Mouse Anti-Chlorpheniramine monoclonal antibody, clone CPM

CABT-L4253-100ug 100 ug
EUR 533

Mouse Anti-Chlorpheniramine monoclonal antibody, clone CPM

CABT-L4253-1mg 1 mg
EUR 1313

Mouse Anti-Phosphotyrosine Monoclonal antibody, clone 4G10

CABT-L4295-1mg 1 mg
EUR 897

Mouse Anti-Phosphotyrosine Monoclonal antibody, clone 4G10

CABT-L4295-5mg 5 mg
EUR 2405

Mouse Anti-CPV monoclonal antibody, clone 6H8

CABT-RM017 1 mg
EUR 819

Mouse Anti-CPV monoclonal antibody, clone 9I8

CABT-RM018 1 mg
EUR 819

Mouse Anti-BCoV monoclonal antibody, clone 6B5

CABT-RM020 1 mg
EUR 819

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