TNF monoclonal antibody in a mouse inflammatory bowel illness mannequin

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October 7, 2020 Tauns 0 Comments

Security and Tolerability of three CGRP Monoclonal Antibodies in Apply: A Retrospective Cohort Examine

Goal: We sought to evaluate the protection and tolerability of three calcitonin gene-related peptide (CGRP) monoclonal antibodies in sufferers with power migraine who have failed a number of lessons of migraine preventive therapies.

Background: CGRP is a crucial neuromodulator implicated within the pathogenesis of migraine. They’re accepted for the therapy of episodic and power migraine. In present medical observe, CGRP monoclonal antibodies are utilized in sufferers who’ve failed a number of preventive brokers, however security, tolerability, and efficacy haven’t been properly described in real-world populations outdoors of medical trials.

Strategies: This was a single-center, observational, retrospective research in adults with power migraine handled with a CGRP monoclonal antibody between Might 1, 2018 and September 30, 2019. Charts have been reviewed at 0, 3, and 6 months after therapy.

Outcomes: From Might 1, 2018 to September 30, 2019, 77 sufferers with power migraine have been prescribed 90 therapy trials of a CGRP monoclonal antibody. Sufferers reported antagonistic outcomes in 2/5 (40.0%) with erenumab 70 mg, 32/46 (69.6%) with erenumab 140 mg, 8/16 (50.0%) with fremanezumab, and 15/23 (65.2%) with galcanezumab. Essentially the most frequent antagonistic results have been constipation and injection web site reactions.

Antagonistic results resulting in discontinuation have been reported as follows: erenumab 70 mg 1/5 (20.0%), erenumab 140 mg 10/46 (22.7%), fremanezumab 1/16 (6.3%), and galcanezumab 1/23 (4.3%), with 13/90 (14.4%) discontinuation fee total. Essentially the most frequent causes for discontinuation have been lack of enchancment in 17/90 (18.9%) and constipation in 4/90 (4.4%). A 50% or higher discount within the variety of extreme headache days monthly was achieved for 32/66 (48.5%) at Three months and 17/48 (35.4%) at 6 months.

Conclusions: In sufferers with power migraine, the three CGRP monoclonal antibodies have been properly tolerated, and decreased the variety of extreme headache days.

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Myeloperoxidase (MPO) mouse monoclonal antibody, clone 4B3
4M43-4B3 1 mg Ask for price

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:3E7]
E45M21342 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 3E7]
E45M21342V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:1D3]
E45M21345 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 1D3]
E45M21345V-2 50 ul
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Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:6A9]
E45M21350 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 6A9]
E45M21350V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:4B7]
E45M21383 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 4B7]
E45M21383V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:5G2]
E45M21384 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 5G2]
E45M21384V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:5H2]
E45M21385 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 5H2]
E45M21385V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:2G4]
E45M21390 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 2G4]
E45M21390V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:2G3]
E45M21391 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 2G3]
E45M21391V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:2F3]
E45M21395 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 2F3]
E45M21395V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:8E8]
E45M21396 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 8E8]
E45M21396V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:5G5]
E45M21397 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 5G5]
E45M21397V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:1B5]
E45M21421 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 1B5]
E45M21421V-2 50 ul
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Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:2F2]
E45M21422 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 2F2]
E45M21422V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:4D4]
E45M21426 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 4D4]
E45M21426V-2 50 ul
EUR 195

Myeloperoxidase (MPO) mouse monoclonal antibody, clone 16E3
4M43-16E3 1 mg Ask for price

Myeloperoxidase (MPO) mouse monoclonal antibody, clone 17G2
4M43-17G2 1 mg Ask for price

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Myeloperoxidase (MPO) mouse monoclonal antibody, clone 19G8
4M43-19G8 1 mg Ask for price

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:3A11]
E45M21341 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 3A11]
E45M21341V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:2A11]
E45M21343 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 2A11]
E45M21343V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:3E10]
E45M21344 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 3E10]
E45M21344V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:4G10]
E45M21348 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 4G10]
E45M21348V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:11C7]
E45M21386 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 11C7]
E45M21386V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:2E12]
E45M21394 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 2E12]
E45M21394V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:8F12]
E45M21398 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 8F12]
E45M21398V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:2E1C7]
E45M21382 100 ug
EUR 595

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 2E1C7]
E45M21382V-2 50 ul
EUR 195

Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone:2E1E1]
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Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone 2E1E1]
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Myeloperoxidase (MPO) mouse monoclonal antibody, clone 2C7, PE
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Myeloperoxidase (MPO) Monoclonal Antibody
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Myeloperoxidase (MPO) Monoclonal Antibody
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Myeloperoxidase (MPO) Monoclonal Antibody
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Myeloperoxidase (MPO) Monoclonal Antibody
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Myeloperoxidase (MPO) Monoclonal Antibody
MBS2569801-02mL 0.2mL
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Myeloperoxidase (MPO) Monoclonal Antibody
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EUR 165

Myeloperoxidase (MPO) Monoclonal Antibody
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EUR 1225

Myeloperoxidase (MPO) Monoclonal Antibody
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Myeloperoxidase(MPO) Monoclonal Antibody
PA6663-100uL 100uL
EUR 150
Description: Unconjugated

Myeloperoxidase(MPO) Monoclonal Antibody
PA6663-200uL 200uL
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Myeloperoxidase(MPO) Monoclonal Antibody
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Myeloperoxidase(MPO) Monoclonal Antibody
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Myeloperoxidase (MPO) mouse monoclonal antibody, clone 266.6K2, FITC
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Mouse Monoclonal Anti-Mouse Myeloperoxidase (MPO) IgG
MPO12-M 100 ul
EUR 578.4

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Monoclonal mouse anti-human myeloperoxidase (MPO)  
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Myeloperoxidase (MPO) mouse monoclonal antibody, clone 2D4, Biotin
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Myeloperoxidase (MPO) mouse monoclonal antibody, clone 4A4, Purified
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Myeloperoxidase (MPO) mouse monoclonal antibody, clone 2A11, Purified
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Monoclonal Antibody to Myeloperoxidase (MPO)
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Monoclonal Antibody to Myeloperoxidase (MPO)
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Monoclonal Antibody to Myeloperoxidase (MPO)
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Myeloperoxidase (MPO) mouse monoclonal antibody, clone MPO421-8B2, FITC
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Myeloperoxidase (MPO) mouse monoclonal antibody, clone 266-6K1, Biotin
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Myeloperoxidase (MPO) Monoclonal Antibody (Human)
4-MAA601Hu22
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO)

Myeloperoxidase (MPO) mouse monoclonal antibody, clone 266.6K2, Aff - Purified
AM39035PU-N 1 ml Ask for price

Myeloperoxidase (MPO) mouse monoclonal antibody, clone 266-6K1, Purified
AM26227PU-N 100 µg Ask for price

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AM32277PU-N 100 µg Ask for price

Myeloperoxidase (MPO) Monoclonal Antibody (Bovine)
4-MAA601Bo21
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO)

Myeloperoxidase (MPO) mouse monoclonal antibody, clone MPO421-8B2, Purified
AM26774PU-N 100 µg Ask for price

Myeloperoxidase (MPO) Monoclonal Antibody (Human), PE
4-MAA601Hu22-PE
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO). This antibody is labeled with PE.

Myeloperoxidase (MPO) Monoclonal Antibody (Bovine), PE
4-MAA601Bo21-PE
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO). This antibody is labeled with PE.

Myeloperoxidase (MPO) Monoclonal Antibody (Human), APC
4-MAA601Hu22-APC
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO). This antibody is labeled with APC.

Myeloperoxidase (MPO) Monoclonal Antibody (Human), Cy3
4-MAA601Hu22-Cy3
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO). This antibody is labeled with Cy3.

Myeloperoxidase (MPO) Monoclonal Antibody (Human), HRP
4-MAA601Hu22-HRP
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO). This antibody is labeled with HRP.

Myeloperoxidase (MPO) Monoclonal Antibody (Bovine), APC
4-MAA601Bo21-APC
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO). This antibody is labeled with APC.

Myeloperoxidase (MPO) Monoclonal Antibody (Bovine), Cy3
4-MAA601Bo21-Cy3
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO). This antibody is labeled with Cy3.

Myeloperoxidase (MPO) Monoclonal Antibody (Bovine), HRP
4-MAA601Bo21-HRP
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO). This antibody is labeled with HRP.

Myeloperoxidase (MPO) Monoclonal Antibody (Human), FITC
4-MAA601Hu22-FITC
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO). This antibody is labeled with FITC.

Mouse Anti-Mouse Myeloperoxidase (MPO) IgM Monoclonal Antibody (mAb), Clone 8B3A6
7160 1 mg/ml x 0.1 ml
EUR 246
Description: Inflammation

Anti-Human Myeloperoxidase (ABT-MPO) Mouse Monoclonal Antibody
MBS9511046-005mL 0.05mL
EUR 190

Anti-Human Myeloperoxidase (ABT-MPO) Mouse Monoclonal Antibody
MBS9511046-01mL 0.1mL
EUR 255

Anti-Human Myeloperoxidase (ABT-MPO) Mouse Monoclonal Antibody
MBS9511046-02mL 0.2mL
EUR 325

Anti-Human Myeloperoxidase (ABT-MPO) Mouse Monoclonal Antibody
MBS9511046-1mL 1mL
EUR 580

Anti-Human Myeloperoxidase (ABT-MPO) Mouse Monoclonal Antibody
MBS9511046-5x1mL 5x1mL
EUR 2455

Myeloperoxidase (MPO) Monoclonal Antibody (Bovine), FITC
4-MAA601Bo21-FITC
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO). This antibody is labeled with FITC.

Myeloperoxidase/MPO Recombinant Mouse Monoclonal Antibody [Clone rMPO/6904]
MBS4382100-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

Myeloperoxidase/MPO Recombinant Mouse Monoclonal Antibody [Clone rMPO/6904]
MBS4382100-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

Myeloperoxidase/MPO Recombinant Mouse Monoclonal Antibody [Clone rMPO/6904]
MBS4382100-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

Myeloperoxidase/MPO Recombinant Mouse Monoclonal Antibody [Clone rMPO/6904]
MBS4382100-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

Myeloperoxidase/MPO Recombinant Mouse Monoclonal Antibody [Clone rMPO/6904]
MBS4382100-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

Mouse Anti-Mouse Myeloperoxidase (MPO) IgG3 Monoclonal Antibody (mAb), Clone 3B6A10
7159 1 mg/ml x 0.1 ml
EUR 246
Description: Inflammation

PE Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2130397-INQUIRE INQUIRE Ask for price

APC Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2130398-INQUIRE INQUIRE Ask for price

Cy3 Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2130399-INQUIRE INQUIRE Ask for price

HRP Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2130402-INQUIRE INQUIRE Ask for price

PE-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2107516-INQUIRE INQUIRE Ask for price

PE-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2118328-INQUIRE INQUIRE Ask for price

APC_Cy7 Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2130396-INQUIRE INQUIRE Ask for price

FITC Linked Monoclonal Antibody to Myeloperoxidase (MPO)
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PE-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2044807-INQUIRE INQUIRE Ask for price

Myeloperoxidase (MPO) Monoclonal Antibody (Human), APC-Cy7
4-MAA601Hu22-APC-Cy7
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO). This antibody is labeled with APC-Cy7.

APC-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2107518-INQUIRE INQUIRE Ask for price

Cy3-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2107520-INQUIRE INQUIRE Ask for price

HRP-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2107526-INQUIRE INQUIRE Ask for price

HRP-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2115640-INQUIRE INQUIRE Ask for price

APC-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2119672-INQUIRE INQUIRE Ask for price

Cy3-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2121159-INQUIRE INQUIRE Ask for price

APC-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2044809-INQUIRE INQUIRE Ask for price

Cy3-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2044811-INQUIRE INQUIRE Ask for price

HRP-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2044815-INQUIRE INQUIRE Ask for price

Myeloperoxidase (MPO) Monoclonal Antibody (Human), Biotinylated
4-MAA601Hu22-Biotin
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Description: A Mouse monoclonal antibody against Human Myeloperoxidase (MPO). This antibody is labeled with Biotin.

Myeloperoxidase (MPO) Monoclonal Antibody (Bovine), APC-Cy7
4-MAA601Bo21-APC-Cy7
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO). This antibody is labeled with APC-Cy7.

FITC-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2107524-INQUIRE INQUIRE Ask for price

FITC-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2114314-INQUIRE INQUIRE Ask for price

Biotin Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2130400-INQUIRE INQUIRE Ask for price

FITC-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2044813-INQUIRE INQUIRE Ask for price

Genorise® Human Myeloperoxidase (MPO) Monoclonal Antibody
GR126119 100 µg
EUR 398

Botin-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2107522-INQUIRE INQUIRE Ask for price

Myeloperoxidase (MPO) Monoclonal Antibody (Bovine), Biotinylated
4-MAA601Bo21-Biotin
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Description: A Mouse monoclonal antibody against Bovine Myeloperoxidase (MPO). This antibody is labeled with Biotin.

Biotin-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2090923-INQUIRE INQUIRE Ask for price

Biotin-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2112765-INQUIRE INQUIRE Ask for price

APC/Cy7 Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2107514-INQUIRE INQUIRE Ask for price

Myeloperoxidase/MPO Recombinant Rabbit Monoclonal Antibody [Clone MPO/33R]
MBS4382101-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

Myeloperoxidase/MPO Recombinant Rabbit Monoclonal Antibody [Clone MPO/33R]
MBS4382101-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

Myeloperoxidase/MPO Recombinant Rabbit Monoclonal Antibody [Clone MPO/33R]
MBS4382101-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

Myeloperoxidase/MPO Recombinant Rabbit Monoclonal Antibody [Clone MPO/33R]
MBS4382101-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

Myeloperoxidase/MPO Recombinant Rabbit Monoclonal Antibody [Clone MPO/33R]
MBS4382101-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

APC-Cy7 Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2116984-INQUIRE INQUIRE Ask for price

APC/CY7-Linked Monoclonal Antibody to Myeloperoxidase (MPO)
MBS2044805-INQUIRE INQUIRE Ask for price

Anti-Human Myeloperoxidase (ABT-MPO) Mouse Monoclonal Antibody (Ready to Use)
MBS9511456-12mLRTU 12mL(RTU)
EUR 530

 

Refractory short-lasting unilateral neuralgiform headache assaults with conjunctival injection and tearing conscious of anti-calcitonin gene-related peptide monoclonal antibodies: A case report

 

Background: Quick-lasting unilateral neuralgiform headache assaults with conjunctival injection and tearing (SUNCT) is a uncommon however severely disabling variant throughout the spectrum of trigeminal autonomic cephalalgia missing evidence-based therapy.

 

Case: We report a case of power SUNCT in a 67-year-old man refractory to numerous guideline-conforming therapy makes an attempt responding excellently to galcanezumab.

 

Conclusions: This case report signifies that monoclonal antibodies in opposition to calcitonin gene-related peptide, particularly galcanezumab, is perhaps a therapy possibility for SUNCT warranting additional investigation.

A minimal physiologically based mostly pharmacokinetic mannequin to characterize colon TNF suppression and therapy results of an anti-TNF monoclonal antibody in a mouse inflammatory bowel illness mannequin

 

Biotherapeutic medication in opposition to tumor necrosis issue (TNF) are efficient therapies for average to extreme inflammatory bowel illness (IBD). Right here, we evaluated CNTO 5048, an antimurine TNF surrogate monoclonal antibody (mAb), in a CD45RBexcessive adoptive T cell switch mouse colitis mannequin, which permits examination of the early immunological occasions related to intestine irritation and the therapeutic results.

The research was designed to quantitatively perceive the consequences of IBD on CNTO 5048 disposition, the flexibility of CNTO 5048 to neutralize pathogenic TNF on the colon underneath illness circumstances, and the influence of dosing routine on CNTO 5048 therapy impact. CNTO 5048 and TNF concentrations in each mice serum and colon homogenate have been additionally measured.

Free TNF concentrations in colon, however not in serum, have been proven to correlate properly with the colon pharmacodynamic readout, such because the summed histopathology rating and neutrophil rating. A minimal physiologically based mostly pharmacokinetic (mPBPK) mannequin was developed to characterize CNTO 5048 PK and disposition, in addition to colon soluble TNF goal engagement (TE).

The mPBPK/TE mannequin fairly captured the noticed information and supplied a quantitative understanding of an anti-TNF mAb on its colon TNF suppression and therapeutic impact in a physiologically related IBD animal mannequin.

These outcomes additionally supplied insights into the potential advantages of utilizing induction doses for the therapy of IBD sufferers.

 

Calprotectin (CALPRO) Monoclonal Antibody (Human), Cy3
4-MAK504Hu21-Cy3
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  • 20ul
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  • 1ml
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Description: A Mouse monoclonal antibody against Human Calprotectin (CALPRO). This antibody is labeled with Cy3.

Calprotectin (CALPRO) Monoclonal Antibody (Human), HRP
4-MAK504Hu21-HRP
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  • 20ul
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  • 1ml
  • 10ml
Description: A Mouse monoclonal antibody against Human Calprotectin (CALPRO). This antibody is labeled with HRP.

Calprotectin (CALPRO) Monoclonal Antibody (Human), FITC
4-MAK504Hu21-FITC
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  • 20ul
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  • 1ml
  • 10ml
Description: A Mouse monoclonal antibody against Human Calprotectin (CALPRO). This antibody is labeled with FITC.

Calprotectin (CALPRO) Monoclonal Antibody (Human), Biotinylated
4-MAK504Hu21-Biotin
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  • 20ul
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  • 1ml
  • 10ml
Description: A Mouse monoclonal antibody against Human Calprotectin (CALPRO). This antibody is labeled with Biotin.

PE-Linked Monoclonal Antibody to Calprotectin (CALPRO)
MBS2110726-INQUIRE INQUIRE Ask for price

Calprotectin (CALPRO) Monoclonal Antibody (Human), APC-Cy7
4-MAK504Hu21-APC-Cy7
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  • 20ul
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Description: A Mouse monoclonal antibody against Human Calprotectin (CALPRO). This antibody is labeled with APC-Cy7.

APC-Linked Monoclonal Antibody to Calprotectin (CALPRO)
MBS2110728-INQUIRE INQUIRE Ask for price

Cy3-Linked Monoclonal Antibody to Calprotectin (CALPRO)
MBS2110730-INQUIRE INQUIRE Ask for price

HRP-Linked Monoclonal Antibody to Calprotectin (CALPRO)
MBS2110736-INQUIRE INQUIRE Ask for price

FITC-Linked Monoclonal Antibody to Calprotectin (CALPRO)
MBS2110734-INQUIRE INQUIRE Ask for price

Botin-Linked Monoclonal Antibody to Calprotectin (CALPRO)
MBS2110732-INQUIRE INQUIRE Ask for price

Biotin-Linked Monoclonal Antibody to Calprotectin (CALPRO)
LAK504Hu72 250 ul
EUR 385

APC/Cy7 Linked Monoclonal Antibody to Calprotectin (CALPRO)
MBS2110724-INQUIRE INQUIRE Ask for price

Mouse monoclonal Calprotectin antibody
MBS5305336-1mg 1mg
EUR 610

Mouse monoclonal Calprotectin antibody
MBS5305336-5x1mg 5x1mg
EUR 2585

Monoclonal Anti-human calprotectin antibody.
TMC141-0.2MG 0.2mg
EUR 169
Description: This antibody reacts only with human calprotectin. This antibody can be paired with TMC142 for ELISA.

Monoclonal Anti-human calprotectin antibody.
TMC141-1MG 1mg
EUR 569
Description: This antibody reacts only with human calprotectin. This antibody can be paired with TMC142 for ELISA.

Monoclonal Anti-human calprotectin antibody.
TMC142-0.2MG 0.2mg
EUR 169
Description: This antibody reacts only with human calprotectin. This antibody can be paired with TMC141 for ELISA.

Monoclonal Anti-human calprotectin antibody.
TMC142-1MG 1mg
EUR 569
Description: This antibody reacts only with human calprotectin. This antibody can be paired with TMC141 for ELISA.

Calprotectin (Macrophage Marker) Mouse Monoclonal Antibody
MBS439169-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

Calprotectin (Macrophage Marker) Mouse Monoclonal Antibody
MBS439169-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

Calprotectin (Macrophage Marker) Mouse Monoclonal Antibody
MBS439169-01mgWithoutBSAat1mgmL 0.1mg(WithoutBSAat1mg/mL)
EUR 405

Calprotectin (Macrophage Marker) Mouse Monoclonal Antibody
MBS439169-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

Calprotectin (Macrophage Marker) Mouse Monoclonal Antibody
MBS439169-5x01mgWithoutBSAat1mgmL 5x0.1mg(WithoutBSAat1mg/mL)
EUR 1725

Calprotectin (CALPRO) Polyclonal Antibody (Mouse)
4-PAK504Mu01
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  • 20ul
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  • 1ml
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Description: A Rabbit polyclonal antibody against Mouse Calprotectin (CALPRO)

Calprotectin (CALPRO) Antibody
20-abx132157
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  • 10 ug
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  • 1 mg

Calprotectin (CALPRO) Antibody
20-abx132274
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  • 20 ug
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  • 1 mg

Calprotectin (CALPRO) Polyclonal Antibody (Mouse), PE
4-PAK504Mu01-PE
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  • 20ul
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Description: A Rabbit polyclonal antibody against Mouse Calprotectin (CALPRO). This antibody is labeled with PE.

Calprotectin (CALPRO) Polyclonal Antibody (Mouse), APC
4-PAK504Mu01-APC
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  • 20ul
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  • 1ml
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Description: A Rabbit polyclonal antibody against Mouse Calprotectin (CALPRO). This antibody is labeled with APC.

Calprotectin (CALPRO) Polyclonal Antibody (Mouse), Cy3
4-PAK504Mu01-Cy3
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  • 20ul
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  • 1ml
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Description: A Rabbit polyclonal antibody against Mouse Calprotectin (CALPRO). This antibody is labeled with Cy3.

Calprotectin (CALPRO) Polyclonal Antibody (Mouse), HRP
4-PAK504Mu01-HRP
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  • 20ul
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  • 1ml
  • 10ml
Description: A Rabbit polyclonal antibody against Mouse Calprotectin (CALPRO). This antibody is labeled with HRP.

Calprotectin (CALPRO) Polyclonal Antibody (Mouse), FITC
4-PAK504Mu01-FITC
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  • 20ul
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  • 1ml
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Description: A Rabbit polyclonal antibody against Mouse Calprotectin (CALPRO). This antibody is labeled with FITC.

Calprotectin (CALPRO) Antibody (Biotin)
20-abx274560
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  • 10 ug
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  • 1 mg

Calprotectin (CALPRO) Polyclonal Antibody (Mouse), Biotinylated
4-PAK504Mu01-Biotin
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  • 20ul
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Description: A Rabbit polyclonal antibody against Mouse Calprotectin (CALPRO). This antibody is labeled with Biotin.

Mouse Calprotectin (CALPRO) Protein
20-abx167392
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  • 10 ug
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  • 1 mg

Calprotectin (CALPRO) Polyclonal Antibody (Mouse), APC-Cy7
4-PAK504Mu01-APC-Cy7
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  • 20ul
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Description: A Rabbit polyclonal antibody against Mouse Calprotectin (CALPRO). This antibody is labeled with APC-Cy7.

Calprotectin (CALPRO) Polyclonal Antibody
CAU29130-100ul 100ul
EUR 302.4

Calprotectin (CALPRO) Polyclonal Antibody
CAU29130-200ul 200ul
EUR 378

Calprotectin (CALPRO) Polyclonal Antibody
CAU30142-100ul 100ul
EUR 313

Calprotectin (CALPRO) Polyclonal Antibody
CAU30142-200ul 200ul
EUR 390.6

Calprotectin (CALPRO) Polyclonal Antibody
MBS2090434-INQUIRE INQUIRE Ask for price

Mouse Calprotectin (CALPRO) ELISA Kit
abx257892-96tests 96 tests
EUR 904.8

Mouse Calprotectin (CALPRO) ELISA Kit
EKU10699-48T 48T
EUR 571.55

Mouse Calprotectin (CALPRO) ELISA Kit
EKU10699-5x96T 5x96T
EUR 3878.38

Mouse Calprotectin (CALPRO) ELISA Kit
EKU10699-96T 96T
EUR 816.5

Mouse Calprotectin (CALPRO) ELISA Kit
EKN51810-48T 48T
EUR 355.6

Mouse Calprotectin (CALPRO) ELISA Kit
EKN51810-5x96T 5x96T
EUR 2413

Mouse Calprotectin (CALPRO) ELISA Kit
EKN51810-96T 96T
EUR 508

Mouse Calprotectin (CALPRO) ELISA Kit
MBS2098124-10x96StripWells 10x96-Strip-Wells
EUR 5455

Mouse Calprotectin (CALPRO) ELISA Kit
MBS2098124-24StripWells 24-Strip-Wells
EUR 365

Mouse Calprotectin (CALPRO) ELISA Kit
MBS2098124-48StripWells 48-Strip-Wells
EUR 550

Mouse Calprotectin (CALPRO) ELISA Kit
MBS2098124-5x96StripWells 5x96-Strip-Wells
EUR 2985

Mouse Calprotectin (CALPRO) ELISA Kit
MBS2098124-96StripWells 96-Strip-Wells
EUR 740

Mouse Calprotectin (CALPRO) ELISA Kit
MBS2706867-10x96StripWells 10x96-Strip-Wells
EUR 3215

Mouse Calprotectin (CALPRO) ELISA Kit
MBS2706867-24StripWells 24-Strip-Wells
EUR 255

Mouse Calprotectin (CALPRO) ELISA Kit
MBS2706867-48StripWells 48-Strip-Wells
EUR 340

Mouse Calprotectin (CALPRO) ELISA Kit
MBS2706867-5x96StripWells 5x96-Strip-Wells
EUR 1675

Mouse Calprotectin (CALPRO) ELISA Kit
MBS2706867-96StripWells 96-Strip-Wells
EUR 430

Mouse Calprotectin (CALPRO) ELISA Kit
SEK504Mu-10x96wellstestplate 10x96-wells test plate
EUR 5834.88
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Calprotectin (CALPRO) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Calprotectin (CALPRO) ELISA Kit
SEK504Mu-1x48wellstestplate 1x48-wells test plate
EUR 585.7
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Calprotectin (CALPRO) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Calprotectin (CALPRO) ELISA Kit
SEK504Mu-1x96wellstestplate 1x96-wells test plate
EUR 785.28
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Calprotectin (CALPRO) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Calprotectin (CALPRO) ELISA Kit
SEK504Mu-5x96wellstestplate 5x96-wells test plate
EUR 3173.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Calprotectin (CALPRO) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse Calprotectin (CALPRO) ELISA Kit
4-SEK504Mu
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  • 1 plate of 96 wells
  • 5 plates of 96 wells
  • 10 plates of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Calprotectin (CALPRO) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Polyclonal Antibody to Calprotectin (CALPRO)
MBS2027713-01mL 0.1mL
EUR 205

Polyclonal Antibody to Calprotectin (CALPRO)
MBS2027713-02mL 0.2mL
EUR 260

Polyclonal Antibody to Calprotectin (CALPRO)
MBS2027713-05mL 0.5mL
EUR 460

Polyclonal Antibody to Calprotectin (CALPRO)
MBS2027713-1mL 1mL
EUR 560

Polyclonal Antibody to Calprotectin (CALPRO)
MBS2027713-5mL 5mL
EUR 1560

Calprotectin (CALPRO) Polyclonal Antibody (Human)
4-PAK504Hu01
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  • 20ul
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Description: A Rabbit polyclonal antibody against Human Calprotectin (CALPRO)

Calprotectin (CALPRO) Polyclonal Antibody (Human), PE
4-PAK504Hu01-PE
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  • 20ul
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Description: A Rabbit polyclonal antibody against Human Calprotectin (CALPRO). This antibody is labeled with PE.

Active Calprotectin (CALPRO)
APK504Hu61 10ug
EUR 350

Calprotectin (CALPRO) Polyclonal Antibody (Human), APC
4-PAK504Hu01-APC
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  • 20ul
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Description: A Rabbit polyclonal antibody against Human Calprotectin (CALPRO). This antibody is labeled with APC.

Calprotectin (CALPRO) Polyclonal Antibody (Human), Cy3
4-PAK504Hu01-Cy3
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  • 20ul
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  • 1ml
  • 10ml
Description: A Rabbit polyclonal antibody against Human Calprotectin (CALPRO). This antibody is labeled with Cy3.

Calprotectin (CALPRO) Polyclonal Antibody (Human), HRP
4-PAK504Hu01-HRP
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  • 20ul
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  • 1ml
  • 10ml
Description: A Rabbit polyclonal antibody against Human Calprotectin (CALPRO). This antibody is labeled with HRP.

Calprotectin (CALPRO) Polyclonal Antibody (Human), FITC
4-PAK504Hu01-FITC
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  • 20ul
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Description: A Rabbit polyclonal antibody against Human Calprotectin (CALPRO). This antibody is labeled with FITC.

Eukaryotic Calprotectin (CALPRO)
EPK504Hu61 10ug
EUR 292

Eukaryotic Calprotectin (CALPRO)
MBS2125393-001mg 0.01mg
EUR 230

Eukaryotic Calprotectin (CALPRO)
MBS2125393-005mg 0.05mg
EUR 475

Eukaryotic Calprotectin (CALPRO)
MBS2125393-01mg 0.1mg
EUR 725

Eukaryotic Calprotectin (CALPRO)
MBS2125393-02mg 0.2mg
EUR 895

Eukaryotic Calprotectin (CALPRO)
MBS2125393-05mg 0.5mg
EUR 1735

Eukaryotic Calprotectin (CALPRO)
RPU59290-100ug 100ug
EUR 1026.1

Eukaryotic Calprotectin (CALPRO)
RPU59290-1mg 1mg
EUR 4264.7

Eukaryotic Calprotectin (CALPRO)
RPU59290-50ug 50ug
EUR 761.8

Recombinant Calprotectin (CALPRO)
MBS2031156-001mg 0.01mg
EUR 190

Recombinant Calprotectin (CALPRO)
MBS2031156-005mg 0.05mg
EUR 345

Recombinant Calprotectin (CALPRO)
MBS2031156-01mg 0.1mg
EUR 525

Recombinant Calprotectin (CALPRO)
MBS2031156-02mg 0.2mg
EUR 640

Recombinant Calprotectin (CALPRO)
MBS2031156-05mg 0.5mg
EUR 1230

Recombinant Calprotectin (CALPRO)
MBS2097578-001mg 0.01mg
EUR 180

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