Human Papillomavirus Lineage Variation on Recognition by Neutralizing Monoclonal

tuberculosistest
October 7, 2020 0 Comments

Complete Evaluation of the Antigenic Influence of Human Papillomavirus Lineage Variation on Recognition by Neutralizing Monoclonal Antibodies Raised Towards Lineage A Main Capsid Proteins of Vaccine-Associated Genotypes

Human papillomavirus (HPV) is the causative agent of cervical and different epithelial cancers. Naturally occurring variants of HPV have been categorized into lineages and sublineages primarily based upon their complete genome sequence, however little is thought in regards to the affect of this variety on the construction and performance of viral gene merchandise. The HPV capsid is an icosahedral lattice comprising 72 pentamers of the most important capsid protein (L1) and the related minor capsid protein (L2).

We investigated the potential affect of this genome variation on the capsid antigenicity of lineage and sublineage variants of seven vaccine-relevant, oncogenic HPV genotypes through the use of a big panel of monoclonal antibodies (MAbs) raised in opposition to the L1 proteins of lineage A antigens.

Every genotype had at the least one variant that displayed a ≥4-fold lowered neutralizing antibody sensitivity in opposition to at the least one MAb, demonstrating that naturally occurring variation can have an effect on a number of useful antigenic determinants on the HPV capsid. For HPV16, HPV18, HPV31 and HPV45, the general affect was of a low magnitude.

For HPV33 (sublineages A2 and A3 and lineages B and C), HPV52 (lineage D) and HPV58 (lineage C), nonetheless, variant residues within the indicated lineage and sublineages lowered their sensitivity to neutralization by all MAbs by as much as 1000-fold, suggesting the presence of key antigenic determinants on the floor of those capsids. These determinants have been resolved additional by site-directed mutagenesis. These information enhance our understanding of the affect of naturally occurring variation on the antigenicity of the HPV capsid of vaccine-relevant oncogenic HPV genotypes.

IMPORTANCEHuman papillomavirus (HPV) is the causative agent of cervical and another epithelial cancers. HPV vaccines generate useful (neutralizing) antibodies that concentrate on the virus particles (or capsids) of the most typical HPV cancer-causing genotypes.

Every genotype includes variant types which have arisen over millennia and which embody modifications inside the capsid proteins. On this research, we explored the potential for these naturally occurring variant capsids to affect recognition by neutralizing monoclonal antibodies.

All genotypes included at the least one variant kind that exhibited lowered recognition by at the least one antibody, with some genotypes affected greater than others. These information spotlight the affect of naturally occurring variation on the construction of the HPV capsid proteins of vaccine-relevant oncogenic HPV genotypes.

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tuberculosistest

PDGFR

ABF5489 100 ug
EUR 438

PDGFR

ABF8053 100 ug
EUR 438

PDGFR ? Polyclonal Antibody

ES8919-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against PDGFR ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR ? Polyclonal Antibody

ES8919-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PDGFR ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6534-100ul 100ul
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Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6534-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6535-100ul 100ul
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Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6535-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

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ES6536-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6536-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6537-100ul 100ul
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Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6537-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

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Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6544-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6545-100ul 100ul
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Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6545-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6546-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6546-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

PDGFR-? Polyclonal Antibody

ES3165-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES3166-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

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ES3751-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR-? Polyclonal Antibody

ES3995-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

PDGFR-? Polyclonal Antibody

ES3165-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES3166-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES3751-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

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EUR 279
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

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33470-100ul 100ul
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33470-50ul 50ul
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49363-100ul 100ul
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EUR 239

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AF5489 200ul
EUR 304
Description: PDGFR α Antibody detects endogenous levels of total PDGFR α.

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AF6132 200ul
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Description: PDGFR beta Antibody detects endogenous levels of total PDGFR beta.

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AF6133 200ul
EUR 304
Description: PDGFR beta Antibody detects endogenous levels of total PDGFR beta.

PDGFR beta Antibody

ABF6132 100 ug
EUR 438

PDGFR beta Antibody

ABF6133 100 ug
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10R-1809 100 ul
EUR 403
Description: Mouse monoclonal PDGFr beta antibody

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70R-30719 100 ug
EUR 327
Description: Rabbit polyclonal PDGFR alpha antibody

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70R-33642 100 ug
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Description: Rabbit polyclonal PDGFR alpha antibody

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70R-33644 100 ug
EUR 327
Description: Rabbit polyclonal PDGFR alpha antibody

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Description: Rabbit polyclonal PDGFR beta antibody

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70R-50185 100 ul
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70R-50186 100 ul
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Description: Purified Polyclonal PDGFR beta antibody

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70R-51313 100 ul
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Description: Purified Polyclonal PDGFR beta antibody

Monoclonal PDGFRB / PDGFR Beta Antibody (clone 42G12), Clone: 42G12

AMM01839G 0.05mg
EUR 484
Description: A Monoclonal antibody against Human PDGFRB / PDGFR Beta (clone 42G12). The antibodies are raised in Mouse and are from clone 42G12. This antibody is applicable in WB and IHC-P

PDGFR-Alpha Polyclonal Antibody

ABP52166-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human PDGFR-? at AA range: 1010-1090

PDGFR-Alpha Polyclonal Antibody

ABP52166-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human PDGFR-? at AA range: 1010-1090

PDGFR-Alpha Polyclonal Antibody

ABP52166-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human PDGFR-? at AA range: 1010-1090

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ABP52167-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751

PDGFR-Beta Polyclonal Antibody

ABP52167-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751

PDGFR-Beta Polyclonal Antibody

ABP52167-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751

PDGFR-Beta Polyclonal Antibody

ABP52752-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Rat. This PDGFR-Beta antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771

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ABP52752-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Rat. This PDGFR-Beta antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771

PDGFR-Beta Polyclonal Antibody

ABP52752-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Rat. This PDGFR-Beta antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771

PDGFR-Alpha Polyclonal Antibody

ABP52996-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGFR-?

PDGFR-Alpha Polyclonal Antibody

ABP52996-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGFR-?

PDGFR-Alpha Polyclonal Antibody

ABP52996-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGFR-?

PDGFR-Alpha Polyclonal Antibody

ABP55535-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y754

PDGFR-Alpha Polyclonal Antibody

ABP55535-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y754

PDGFR-Alpha Polyclonal Antibody

ABP55535-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y754

PDGFR-Alpha Polyclonal Antibody

ABP55536-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y849

PDGFR-Alpha Polyclonal Antibody

ABP55536-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y849

PDGFR-Alpha Polyclonal Antibody

ABP55536-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y849

PDGFR-Alpha Polyclonal Antibody

ABP55537-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1018

PDGFR-Alpha Polyclonal Antibody

ABP55537-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1018

PDGFR-Alpha Polyclonal Antibody

ABP55537-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1018

PDGFR-Alpha Polyclonal Antibody

ABP55538-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y762

PDGFR-Alpha Polyclonal Antibody

ABP55538-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y762

PDGFR-Alpha Polyclonal Antibody

ABP55538-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y762

PDGFR-Beta Polyclonal Antibody

ABP55545-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009

PDGFR-Beta Polyclonal Antibody

ABP55545-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009

PDGFR-Beta Polyclonal Antibody

ABP55545-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009

PDGFR-Beta Polyclonal Antibody

ABP55546-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021

PDGFR-Beta Polyclonal Antibody

ABP55546-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021

PDGFR-Beta Polyclonal Antibody

ABP55546-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021

PDGFR-Beta Polyclonal Antibody

ABP55547-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740

PDGFR-Beta Polyclonal Antibody

ABP55547-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740

PDGFR-Beta Polyclonal Antibody

ABP55547-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740

PDGFR beta (pY751) Antibody

20-abx133055
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul

PDGFR Alpha Polyclonal Antibody

ABP59867-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of PDGFR Alpha from Human, Mouse, Rat. This PDGFR Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PDGFR ? protein

PDGFR Alpha Polyclonal Antibody

ABP59867-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of PDGFR Alpha from Human, Mouse, Rat. This PDGFR Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PDGFR ? protein

PDGFR Alpha Polyclonal Antibody

ABP59867-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of PDGFR Alpha from Human, Mouse, Rat. This PDGFR Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PDGFR ? protein

PDGFR beta (pT1009) Antibody

20-abx009684
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul

PDGFR beta (pY1021) Antibody

abx011955-100ug 100 ug
EUR 439

PDGFR beta (pY740) Antibody

abx011959-100ug 100 ug
EUR 439

Anti-PDGFR alpha Antibody

A30446 100ul
EUR 397
Description: Rabbit Polyclonal PDGFR alpha Antibody. Validated in IF, IHC and tested in Human, Mouse, Rat.

PDGFR alpha (pY762) Antibody

abx217685-100ug 100 ug
EUR 439

Anti-PDGFR-beta antibody

STJ96376 200 µl
EUR 197
Description: Rabbit polyclonal to PDGFR-beta.

Anti-PDGFR-alpha antibody

STJ96630 200 µl
EUR 197
Description: Rabbit polyclonal to PDGFR-alpha.

Anti-PDGFR-beta antibody

STJ98314 100 µl
EUR 234
Description: Mouse monoclonal to PDGFR-beta.

 

Monoclonal antibody stability will be usefully monitored utilizing the excitation-energy-dependent fluorescence edge-shift

 

Among the many main challenges within the growth of biopharmaceuticals are structural heterogeneity and aggregation. The event of a profitable therapeutic monoclonal antibody (mAb) requires each a extremely energetic and in addition steady molecule.

 

While a variety of experimental (biophysical) approaches exist to trace modifications in stability of proteins, routine prediction of stability stays difficult. The fluorescence pink edge excitation shift (REES) phenomenon is delicate to a variety of modifications in protein construction. Primarily based on latest work, we now have discovered that quantifying the REES impact is extraordinarily delicate to modifications in protein conformational state and dynamics.

 

Given the intense sensitivity, probably this device may present a ‘fingerprint’ of the construction and stability of a protein, which might have purposes within the discovery and growth of biopharamceuticals. As such we now have explored our speculation with a panel of therapeutic mAbs. We show that the quantified REES information present exceptional sensitivity, with the ability to discern between structurally similar antibodies and displaying sensitivity to unfolding and aggregation.

 

The method works throughout a broad focus vary (μg -mg/ml) and is very constant. We present that the method will be utilized alongside conventional characterisation testing inside the context of a compelled degradation research (FDS). We show the method is ready to predict the steadiness of mAbs each within the brief (hours), medium (days) and long-term (months). The method advantages from low technical complexity, is fast and makes use of instrumentation which exists in most biochemistry laboratories with out modification.

TNF-α, His, Mouse

HY-P7417 50ug
EUR 486

TNF-α Rabbit pAb

A11534-100ul 100 ul
EUR 308

TNF-α Rabbit pAb

A11534-200ul 200 ul
EUR 459

TNF-α Rabbit pAb

A11534-20ul 20 ul
EUR 183

TNF-α Rabbit pAb

A11534-50ul 50 ul
EUR 223

TNF-α Rabbit pAb

A0277-100ul 100 ul
EUR 308

TNF-α Rabbit pAb

A0277-200ul 200 ul
EUR 459

TNF-α Rabbit pAb

A0277-20ul 20 ul
EUR 183

TNF-α Rabbit pAb

A0277-50ul 50 ul
EUR 223

Monkey TNF-α ELISPOT antibody pair

CT617-10 10-plate
EUR 528

Monkey TNF-α ELISPOT antibody pair

CT617-20 20-plate
EUR 923

Human TNF-α ELISPOT antibody pair

CT647-10 10-plate
EUR 528

Human TNF-α ELISPOT antibody pair

CT647-20 20-plate
EUR 923

Mouse TNF-α ELISPOT antibody pair

CT661-10 10-plate
EUR 528

Mouse TNF-α ELISPOT antibody pair

CT661-20 20-plate
EUR 923

Rat TNF-α ELISA antibody pair

CT704-10 10-plate
EUR 547

Rat TNF-α ELISA antibody pair

CT704-20 20-plate
EUR 932

Monkey TNF-α ELISA antibody pair

CT717-10 10-plate
EUR 547

Monkey TNF-α ELISA antibody pair

CT717-20 20-plate
EUR 932

Human TNF-α ELISA antibody pair

CT747-10 10-plate
EUR 547

Human TNF-α ELISA antibody pair

CT747-20 20-plate
EUR 932

Mouse TNF-α ELISA antibody pair

CT761-10 10-plate
EUR 547

Mouse TNF-α ELISA antibody pair

CT761-20 20-plate
EUR 932

Marmoset TNF-α ELISA antibody pair

CT772-10 10-plate
EUR 547

Marmoset TNF-α ELISA antibody pair

CT772-20 20-plate
EUR 932

Marmoset TNF-α ELISPOT antibody pair

CT962-10 10-plate
EUR 528

Marmoset TNF-α ELISPOT antibody pair

CT962-20 20-plate
EUR 923

Mouse TNF-alpha ELISA Kit, 96 tests, Quantitative

100-210-TNF 1 kit
EUR 482

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

44100-100ul 100ul
EUR 252

TNF ? Monoclonal Antibody

EM1197-100ul 100ul
EUR 279
Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

TNF ? Monoclonal Antibody

EM1197-50ul 50ul
EUR 207
Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

Recombinant Rabbit Tumor Necrosis Factor α/TNF-α

C082-10ug 10ug
EUR 168
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4.

Recombinant Rabbit Tumor Necrosis Factor α/TNF-α

C082-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4.

Recombinant Rabbit Tumor Necrosis Factor α/TNF-α

C082-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4.

Recombinant Rabbit Tumor Necrosis Factor α/TNF-α

C082-50ug 50ug
EUR 405
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.4.

TNF-α (31-45), human

HY-P1860 1mg
EUR 360

Swine TNF-α ELISA Kit

DEIA-T6108 96T
EUR 533
Description: For the quantitative determination of swine tumor necrosis factor(TNF-α) concentrations in cell culture supernates, serum, and plasma.This package insert must be read in its entirety before using this product.

Mouse TNF-α ELISA kit

DEIA7391 96T
EUR 741
Description: The Mouse Tumor Necrosis Factor Alpha (TNF-α) ELISA Kit is to be used for the vitro quantitative determination of Mouse TNF-α in serum, plasma, tissue lysates, cell culture supernatants and other biological fluids. The Kit is intended for research use only, not for diagnostic or therapeutic procedure. If detection of other special sample, please contact our technical support.

human TNF-α,His tag

E410A13-10 100μg
EUR 694

Recombinant Mouse TNF α Protein

RP00816 10 μg
EUR 183

Rat TNF-α ELISA kit

CT075A 5-plate
EUR 462

Monkey TNF-α ELISPOT kit

CT133-PB2 2-plate
EUR 415

Monkey TNF-α ELISPOT kit

CT133-PB5 5-plate
EUR 568

Monkey TNF-α ELISPOT kit

CT133-PR2 2-plate
EUR 415

Monkey TNF-α ELISPOT kit

CT133-PR5 5-plate
EUR 556

Monkey TNF-α ELISPOT kit

CT133-T2 2-plate
EUR 360

Monkey TNF-α ELISPOT kit

CT133-T5 5-plate
EUR 579

Monkey TNF-α ELISA kit

CT148A 5-plate
EUR 462

Human TNF-α ELISA kit

CT209A 5-plate
EUR 462

Human TNF-α ELISPOT kit

CT237-PB2 2-plate
EUR 415

Human TNF-α ELISPOT kit

CT237-PB5 5-plate
EUR 568

Human TNF-α ELISPOT kit

CT237-PR2 2-plate
EUR 415

Human TNF-α ELISPOT kit

CT237-PR5 5-plate
EUR 556

Human TNF-α ELISPOT kit

CT237-T2 2-plate
EUR 360

Human TNF-α ELISPOT kit

CT237-T5 5-plate
EUR 579

Mouse TNF-α ELISA kit

CT303A 5-plate
EUR 462

Mouse TNF-α ELISPOT kit

CT322-PB2 2-plate
EUR 415

Mouse TNF-α ELISPOT kit

CT322-PB5 5-plate
EUR 568

Mouse TNF-α ELISPOT kit

CT322-PR2 2-plate
EUR 415

Mouse TNF-α ELISPOT kit

CT322-PR5 5-plate
EUR 556

Mouse TNF-α ELISPOT kit

CT322-T2 2-plate
EUR 360

Mouse TNF-α ELISPOT kit

CT322-T5 5-plate
EUR 579

Marmoset TNF-α ELISA kit

CT342A 5-plate
EUR 462

Marmoset TNF-α ELISPOT kit

CT938-PR2 2-plate
EUR 415

Marmoset TNF-α ELISPOT kit

CT938-PR5 5-plate
EUR 556

α-SMA Monoclonal Antibody

40482-100ul 100ul
EUR 252

α-SMA Monoclonal Antibody

40482-50ul 50ul
EUR 187

α-SMA Monoclonal Antibody

40495-100ul 100ul
EUR 252

α-SMA Monoclonal Antibody

40495-50ul 50ul
EUR 187

anti-STAT6 (6C10)

LF-MA10315 50 ug
EUR 363
Description: Mouse monoclonal to STAT6

Anti-STAT6 (6C10)

YF-MA15643 200 ul
EUR 363
Description: Mouse monoclonal to STAT6

Anti-BRD3 (6C10)

YF-MA16265 50 ug
EUR 363
Description: Mouse monoclonal to BRD3

Anti-BRD3 (6C10)

YF-MA16266 200 ul
EUR 363
Description: Mouse monoclonal to BRD3

Anti-TNF-α (Golimumab), Human IgG1 Antibody

A2141-100 100 µg
EUR 510

Anti-TNF-α (Certolizumab Pegol), Humanized Antibody

A2142-100 100 µg
EUR 510

Bovine tumor necrosis factor α(TNF-α)ELISA KIT

GA-E0017BV-48T 48T
EUR 336

Bovine tumor necrosis factor α(TNF-α)ELISA KIT

GA-E0017BV-96T 96T
EUR 534

Human Tumor necrosis factor α(TNF-α)ELISA Kit

GA-E0122HM-48T 48T
EUR 289

Human Tumor necrosis factor α(TNF-α)ELISA Kit

GA-E0122HM-96T 96T
EUR 466

Mouse Tumor necrosis factor α(TNF-α)ELISA KIT

GA-E0130MS-48T 48T
EUR 336

Mouse Tumor necrosis factor α(TNF-α)ELISA KIT

GA-E0130MS-96T 96T
EUR 534

Rat Tumor necrosis factor α(TNF-α)ELISA Kit

GA-E0772RT-48T 48T
EUR 317

Rat Tumor necrosis factor α(TNF-α)ELISA Kit

GA-E0772RT-96T 96T
EUR 496

Hamster TNF-α(Tumor Necrosis Factor-α) ELISA Kit

EHA0004 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Hamster ;Sensitivity: 1.875pg/ml

Rat Tumor necrosis factor α(TNF-α)ELISA Kit

QY-E10880 96T
EUR 361

Goat Tumor necrosis factor α,TNF-α ELISA KIT

QY-E140007 96T
EUR 413

Sheep Tumor necrosis factor α(TNF-α)ELISA Kit

QY-E140060 96T
EUR 413

Mouse Tumor necrosis factor α(TNF-α)ELISA Kit

QY-E21543 96T
EUR 361

Human Tumor necrosis factor α(TNF-α)ELISA Kit

QY-E00182 96T
EUR 361

Porcine tumor necrosis factor α,TNF-α ELISA Kit

QY-E40006 96T
EUR 394

 

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