Complete Evaluation of the Antigenic Influence of Human Papillomavirus Lineage Variation on Recognition by Neutralizing Monoclonal Antibodies Raised Towards Lineage A Main Capsid Proteins of Vaccine-Associated Genotypes
Human papillomavirus (HPV) is the causative agent of cervical and different epithelial cancers. Naturally occurring variants of HPV have been categorized into lineages and sublineages primarily based upon their complete genome sequence, however little is thought in regards to the affect of this variety on the construction and performance of viral gene merchandise. The HPV capsid is an icosahedral lattice comprising 72 pentamers of the most important capsid protein (L1) and the related minor capsid protein (L2).
We investigated the potential affect of this genome variation on the capsid antigenicity of lineage and sublineage variants of seven vaccine-relevant, oncogenic HPV genotypes through the use of a big panel of monoclonal antibodies (MAbs) raised in opposition to the L1 proteins of lineage A antigens.
Every genotype had at the least one variant that displayed a ≥4-fold lowered neutralizing antibody sensitivity in opposition to at the least one MAb, demonstrating that naturally occurring variation can have an effect on a number of useful antigenic determinants on the HPV capsid. For HPV16, HPV18, HPV31 and HPV45, the general affect was of a low magnitude.
For HPV33 (sublineages A2 and A3 and lineages B and C), HPV52 (lineage D) and HPV58 (lineage C), nonetheless, variant residues within the indicated lineage and sublineages lowered their sensitivity to neutralization by all MAbs by as much as 1000-fold, suggesting the presence of key antigenic determinants on the floor of those capsids. These determinants have been resolved additional by site-directed mutagenesis. These information enhance our understanding of the affect of naturally occurring variation on the antigenicity of the HPV capsid of vaccine-relevant oncogenic HPV genotypes.
IMPORTANCEHuman papillomavirus (HPV) is the causative agent of cervical and another epithelial cancers. HPV vaccines generate useful (neutralizing) antibodies that concentrate on the virus particles (or capsids) of the most typical HPV cancer-causing genotypes.
Every genotype includes variant types which have arisen over millennia and which embody modifications inside the capsid proteins. On this research, we explored the potential for these naturally occurring variant capsids to affect recognition by neutralizing monoclonal antibodies.
All genotypes included at the least one variant kind that exhibited lowered recognition by at the least one antibody, with some genotypes affected greater than others. These information spotlight the affect of naturally occurring variation on the construction of the HPV capsid proteins of vaccine-relevant oncogenic HPV genotypes.
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
Description: A Monoclonal antibody against Human PDGFRB / PDGFR Beta (clone 42G12). The antibodies are raised in Mouse and are from clone 42G12. This antibody is applicable in WB and IHC-P
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Rat. This PDGFR-Beta antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Rat. This PDGFR-Beta antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Rat. This PDGFR-Beta antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771
Immunogen information: Synthesized peptide derived from the Internal region of human PDGFR-?
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGFR-?
Immunogen information: Synthesized peptide derived from the Internal region of human PDGFR-?
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGFR-?
Immunogen information: Synthesized peptide derived from the Internal region of human PDGFR-?
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGFR-?
Immunogen information: Synthesized peptide derived from the C-terminal region of human PDGFR-? at AA range: 1010-1090
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human PDGFR-? at AA range: 1010-1090
Immunogen information: Synthesized peptide derived from the C-terminal region of human PDGFR-? at AA range: 1010-1090
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human PDGFR-? at AA range: 1010-1090
Immunogen information: Synthesized peptide derived from the C-terminal region of human PDGFR-? at AA range: 1010-1090
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human PDGFR-? at AA range: 1010-1090
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751
Immunogen information: Synthesized peptide derived from part region of human PDGFR ? protein
Applications tips:
Description: A polyclonal antibody for detection of PDGFR Alpha from Human, Mouse, Rat. This PDGFR Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PDGFR ? protein
Immunogen information: Synthesized peptide derived from part region of human PDGFR ? protein
Applications tips:
Description: A polyclonal antibody for detection of PDGFR Alpha from Human, Mouse, Rat. This PDGFR Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PDGFR ? protein
Immunogen information: Synthesized peptide derived from part region of human PDGFR ? protein
Applications tips:
Description: A polyclonal antibody for detection of PDGFR Alpha from Human, Mouse, Rat. This PDGFR Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PDGFR ? protein
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y754
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y754
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y754
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y754
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y754
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y754
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y849
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y849
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y849
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y849
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y849
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y849
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1018
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1018
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1018
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1018
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1018
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1018
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y762
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y762
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y762
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y762
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y762
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y762
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740
Immunogen information: Synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740
Applications tips:
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740
Monoclonal antibody stability will be usefully monitored utilizing the excitation-energy-dependent fluorescence edge-shift
Among the many main challenges within the growth of biopharmaceuticals are structural heterogeneity and aggregation. The event of a profitable therapeutic monoclonal antibody (mAb) requires each a extremely energetic and in addition steady molecule.
While a variety of experimental (biophysical) approaches exist to trace modifications in stability of proteins, routine prediction of stability stays difficult. The fluorescence pink edge excitation shift (REES) phenomenon is delicate to a variety of modifications in protein construction. Primarily based on latest work, we now have discovered that quantifying the REES impact is extraordinarily delicate to modifications in protein conformational state and dynamics.
Given the intense sensitivity, probably this device may present a ‘fingerprint’ of the construction and stability of a protein, which might have purposes within the discovery and growth of biopharamceuticals. As such we now have explored our speculation with a panel of therapeutic mAbs. We show that the quantified REES information present exceptional sensitivity, with the ability to discern between structurally similar antibodies and displaying sensitivity to unfolding and aggregation.
The method works throughout a broad focus vary (μg -mg/ml) and is very constant. We present that the method will be utilized alongside conventional characterisation testing inside the context of a compelled degradation research (FDS). We show the method is ready to predict the steadiness of mAbs each within the brief (hours), medium (days) and long-term (months). The method advantages from low technical complexity, is fast and makes use of instrumentation which exists in most biochemistry laboratories with out modification.
Description: A Monoclonal antibody against Human TXN (monoclonal) (M04). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB and IF, E
Description: A Monoclonal antibody against Human STAT6 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB, IHC and IF, E
Description: For the quantitative determination of swine tumor necrosis factor(TNF-α) concentrations in cell culture supernates, serum, and plasma.This package insert must be read in its entirety before using this product.
Description: The Mouse Tumor Necrosis Factor Alpha (TNF-α) ELISA Kit is to be used for the vitro quantitative determination of Mouse TNF-α in serum, plasma, tissue lysates, cell culture supernatants and other biological fluids. The Kit is intended for research use only, not for diagnostic or therapeutic procedure. If detection of other special sample, please contact our technical support.
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A Monoclonal antibody against Human TNF alpha. The antibodies are raised in Rabbit and are from clone EP1085Y. This antibody is applicable in WB
Description: A Monoclonal antibody against Human TNF-alpha. The antibodies are raised in Mouse and are from clone 2A9B9. This antibody is applicable in WB, E
Comparisons between Mnoclonal, Polyclonal and Recombinant antibodies and their benefits: Regular monoclonal antibodies have higher purity, better specificity and less lot-to-lot variations than polyclonal antibodies. Recombinant antibodies, however,
Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000
Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000
Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Buffer: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. Affinity purification
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB;WB:1:500-1:2000
Buffer: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. Affinity purification
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:500-1:2000.IHC:1:50-1:200
Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against TNF. Recognizes TNF from Bovine. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000
Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF;IHC:1:50-1:100, IF:1:100-1:500
Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF;IHC:1:50-1:100, IF:1:100-1:500
Description: A polyclonal antibody against TNF. Recognizes TNF from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:25-1:100
Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against TNF. Recognizes TNF from Sheep. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:1000-1:2000, IHC:1:50-1:100
Description: A polyclonal antibody against TNF. Recognizes TNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:1000-1:2000, IHC:1:50-1:100
Description: A Monoclonal antibody against Human TNF Alpha (clone 2C8). The antibodies are raised in Mouse and are from clone 2C8. This antibody is applicable in IHC-P
, Clone: 42G12)
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 Antibody)
 Antibody)
 Antibody)
 (M04), Clone: 6C10)
Monoclonal TXN Antibody (monoclonal) (M04), Clone: 6C10  (M01), Clone: 6C10)
Monoclonal STAT6 Antibody (monoclonal) (M01), Clone: 6C10 )
Flotillin-1 Mouse Monoclonal Antibody(6C10) 
TNF-α Rabbit pAb 
TNF-α, His, Human 
TNF-α, His, Mouse 
Monkey TNF-α ELISPOT antibody pair 
Human TNF-α ELISPOT antibody pair 
Mouse TNF-α ELISPOT antibody pair 
Rat TNF-α ELISA antibody pair 
Monkey TNF-α ELISA antibody pair 
Human TNF-α ELISA antibody pair 
Mouse TNF-α ELISA antibody pair 
Marmoset TNF-α ELISA antibody pair 
Marmoset TNF-α ELISPOT antibody pair 
Mouse TNF-alpha ELISA Kit, 96 tests, Quantitative  Monoclonal Antibody(6C10))
P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10) 
TNF ? Monoclonal Antibody 
Recombinant Rabbit Tumor Necrosis Factor α/TNF-α 
Swine TNF-α ELISA Kit 
Mouse TNF-α ELISA kit 
Rat TNF-α ELISA kit 
Monkey TNF-α ELISPOT kit 
Monkey TNF-α ELISA kit 
Human TNF-α ELISA kit 
Human TNF-α ELISPOT kit 
Mouse TNF-α ELISPOT kit 
Marmoset TNF-α ELISA kit 
Marmoset TNF-α ELISPOT kit 
human TNF-α，His tag , human)
TNF-α (31-45), human 
Recombinant Mouse TNF α Protein 
α-SMA Monoclonal Antibody )
anti-STAT6 (6C10) )
Anti-STAT6 (6C10) )
Anti-BRD3 (6C10) , Human IgG1 Antibody)
Anti-TNF-α (Golimumab), Human IgG1 Antibody , Humanized Antibody)
Anti-TNF-α (Certolizumab Pegol), Humanized Antibody  ELISA Kit)
Hamster TNF-α(Tumor Necrosis Factor-α) ELISA Kit 
Goat Tumor necrosis factor α,TNF-α ELISA KIT 
PoFAine tumor necrosis factor α,TNF-α ELISA Kit 
Rat Tumor necrosis factor α,TNF-α ELISA KIT 
Monkey Tumor necrosis factor α,TNF-α ELISA KIT 
Mouse Tumor necrosis factor α,TNF-α ELISA KIT 
Human Tumor necrosis factor α,TNF-α ELISA KIT ELISA KIT)
Bovine tumor necrosis factor α(TNF-α)ELISA KIT ELISA Kit)
Rat Tumor necrosis factor α(TNF-α)ELISA Kit ELISA Kit)
Human Tumor necrosis factor α(TNF-α)ELISA Kit ELISA KIT)
Mouse Tumor necrosis factor α(TNF-α)ELISA KIT 
Sheep Tumor necrosis factor α（TNF-α）ELISA Kit ELISA Kit)
Mouse Tumor necrosis factor α(TNF-α)ELISA Kit 
Porcine tumor necrosis factor α,TNF-α ELISA Kit ELISA Kit)
Bovine Tumor necrosis factor α(TNF-α)ELISA Kit 
Canine Tumor necrosis factor α,TNF-α ELISA Kit 
Chicken Tumor necrosis factor α,TNF-α ELISA KIT 
TNF Alpha Monoclonal Antibody 
pAb rabbit anti-rat TNF-α 
mAb mouse anti-human TNF-α )
Recombinant mouse TNF-α (E.coli-derived) 
pAb rabbit anti-mouse TNF-α , human (TFA))
TNF-α (31-45), human (TFA) 
Guinea pig Tumor necrosis factor α,TNF-α ELISA Kit ELISA Kit)
Guinea pig Tumor necrosis factor α(TNF-α)ELISA Kit 
α-tubulin Mouse Monoclonal Antibody )
HSP90 α Monoclonal antibody(1F6) )
HSP90 α Monoclonal antibody(7D6) )
Anti-Thioredoxin / TRX (6C10) 
Recombinant Human Tumor Necrosis Factor-α/TNF-α High Active Mutant 
Human IFN-γ / TNF-α FluoroSpot kit 
Monkey IFN-γ / TNF-α FluoroSpot kit 
17-α-hydoxy progesterone monoclonal antibody 
pAb rabbit anti-rat TNF-α Biotin-labeled 
pAb rabbit anti-mouse TNF-α Biotin labeled 
Human TNF α converting enzyme,TACE ELISA Kit ELISA Kit)
Human TNF α converting enzyme(TACE)ELISA Kit 
Monoclonal TNF alpha Antibody, Clone: EP1085Y 
Mouse anti Canine TNF monoclonal antibody 
Mouse anti Rat TNF monoclonal antibody 
Mouse anti Porcine TNF monoclonal antibody 
Monoclonal TNF-alpha Antibody, Clone: 2A9B9 
TNF Receptor II recombinant monoclonal antibody )
α tubulin Mouse Monoclonal Antibody(Zebrafish Specific)  Monoclonal Antibody(5H5))
α-tubulin (Acetyl Lys40) Monoclonal Antibody(5H5)  ELISA Kit)
Canine TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit  ELISA Kit)
Bovine TNF-α(Tumor necrosis factor alpha) ELISA Kit  ELISA Kit)
Rat TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit  ELISA Kit)
Rabbit TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit  ELISA Kit)
Sheep TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit  ELISA Kit)
Monkey TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit  ELISA Kit)
Porcine TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit  ELISA Kit)
Camel Tumor Necrosis Factor Alpha(TNF-α) ELISA Kit 
Mouse anti Guinea Pig TNF monoclonal antibody 
Rat anti Rhesus Macaque TNF monoclonal antibody 
Anti-TNF Receptor II Rabbit Monoclonal Antibody )
α Skeletal Muslce Actin Mouse Monoclonal Antibody(4B11)  Monoclonal Antibody(4A8)(4A8))
α-tubulin (Acetyl Lys40) Monoclonal Antibody(4A8)(4A8)  ELISA Kit)
Guinea pig TNF-α(Tumor Necrosis Factor Alpha) ELISA Kit 
TNF Antibody 
TNF antibody 
TNF ?? Antibody 
TNF Antibody , Clone: 2C8)
Monoclonal TNF Alpha Antibody (clone 2C8), Clone: 2C8 
α-Internexin Antibody 
Tubulin α Antibody