monoclonal antibodies as powders for reconstitution at excessive focus utilizing spray-drying

tuberculosistest
October 7, 2020 0 Comments

Backside-up pattern preparation for the LC-MS/MS quantification of anti-cancer monoclonal antibodies in bio matrices

Therapeutic monoclonal antibodies (mAbs) are quickly taking on the remedy of many malignancies, and an astonishing variety of mAbs is in improvement. This causes a excessive demand for quantification of mAbs in biomatrices each for measuring therapeutic mAb concentrations and to help pharmacokinetics and pharmacodynamics research.

Conventionally, ligand-binding assays are used for these functions, however LC-MS is gaining reputation. Though intact (top-down) and subunit (middle-down) mAb quantification is reported, signature peptide (bottom-up) quantification is at the moment most advantageous.

This assessment offers an outline of the reported bottom-up mAb quantification strategies in biomatrices in addition to common suggestions concerning signature peptide and inside normal choice, reagent use and optimization of digestion in bottom-up quantification strategies.

 

tuberculosistest
tuberculosistest

Pepsin (PP) Monoclonal Antibody (Human)

4-MAA632Hu22
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsin (PP)

Pepsin (PP) Monoclonal Antibody (Human), PE

4-MAA632Hu22-PE
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsin (PP). This antibody is labeled with PE.

Pepsin (PP) Monoclonal Antibody (Human), APC

4-MAA632Hu22-APC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsin (PP). This antibody is labeled with APC.

Pepsin (PP) Monoclonal Antibody (Human), Cy3

4-MAA632Hu22-Cy3
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsin (PP). This antibody is labeled with Cy3.

Pepsin (PP) Monoclonal Antibody (Human), HRP

4-MAA632Hu22-HRP
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsin (PP). This antibody is labeled with HRP.

Pepsin (PP) Monoclonal Antibody (Human), FITC

4-MAA632Hu22-FITC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsin (PP). This antibody is labeled with FITC.

Pepsin (PP) Monoclonal Antibody (Human), Biotinylated

4-MAA632Hu22-Biotin
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsin (PP). This antibody is labeled with Biotin.

PE-Linked Monoclonal Antibody to Pepsin (PP)

MBS2107564-INQUIRE INQUIRE Ask for price

Pepsin (PP) Monoclonal Antibody (Human), APC-Cy7

4-MAA632Hu22-APC-Cy7
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsin (PP). This antibody is labeled with APC-Cy7.

APC-Linked Monoclonal Antibody to Pepsin (PP)

MBS2107565-INQUIRE INQUIRE Ask for price

Cy3-Linked Monoclonal Antibody to Pepsin (PP)

MBS2107566-INQUIRE INQUIRE Ask for price

HRP-Linked Monoclonal Antibody to Pepsin (PP)

MBS2107569-INQUIRE INQUIRE Ask for price

FITC-Linked Monoclonal Antibody to Pepsin (PP)

MBS2107568-INQUIRE INQUIRE Ask for price

Botin-Linked Monoclonal Antibody to Pepsin (PP)

MBS2107567-INQUIRE INQUIRE Ask for price

APC/Cy7 Linked Monoclonal Antibody to Pepsin (PP)

MBS2107563-INQUIRE INQUIRE Ask for price

Anti Pepsinogen II/PGC mouse monoclonal antibody

MBS157803-01mg 0.1mg
EUR 350

Anti Pepsinogen II/PGC mouse monoclonal antibody

MBS157803-5x01mg 5x0.1mg
EUR 1250

Mouse anti Human Pepsinogen C/PGC Monoclonal Antibody

MBS2543681-006mL 0.06mL
EUR 335

Mouse anti Human Pepsinogen C/PGC Monoclonal Antibody

MBS2543681-012mL 0.12mL
EUR 520

Mouse anti Human Pepsinogen C/PGC Monoclonal Antibody

MBS2543681-02mL 0.2mL
EUR 800

Mouse anti Human PGA4/Pepsinogen A Monoclonal Antibody

MBS2543728-006mL 0.06mL
EUR 250

Mouse anti Human PGA4/Pepsinogen A Monoclonal Antibody

MBS2543728-012mL 0.12mL
EUR 370

Mouse anti Human PGA4/Pepsinogen A Monoclonal Antibody

MBS2543728-02mL 0.2mL
EUR 550

Pepsinogen A mouse monoclonal antibody, clone 8003 (99/12), Purified

BM676 200 µg Ask for price

Pepsinogen II (PGC) mouse monoclonal antibody, clone 90/11, Ig Fraction

BM678 200 µg Ask for price

Pepsinogen II (PGC) mouse monoclonal antibody, clone L10CC10, Ig Fraction

AM32098PU-N 100 µg Ask for price

Monoclonal Antibody to Pepsinogen I

MBS318870-1mg 1mg
EUR 930

Monoclonal Antibody to Pepsinogen I

MBS318870-5x1mg 5x1mg
EUR 4010

Monoclonal Antibody to Pepsinogen II

MBS318871-1mg 1mg
EUR 930

Monoclonal Antibody to Pepsinogen II

MBS318871-5x1mg 5x1mg
EUR 4010

Monoclonal Antibody to Pepsinogen II

MBS318872-1mg 1mg
EUR 930

Monoclonal Antibody to Pepsinogen II

MBS318872-5x1mg 5x1mg
EUR 4010

Monoclonal Antibody to Pepsinogen I

MBS318873-1mg 1mg
EUR 930

Monoclonal Antibody to Pepsinogen I

MBS318873-5x1mg 5x1mg
EUR 4010

Monoclonal Antibody to Pepsinogen I

MBS318874-1mg 1mg
EUR 930

Monoclonal Antibody to Pepsinogen I

MBS318874-5x1mg 5x1mg
EUR 4010

Pepsinogen A (PGA) Monoclonal Antibody

CAU29207-100ul 100ul
EUR 242.9

Pepsinogen A (PGA) Monoclonal Antibody

CAU29207-200ul 200ul
EUR 304.1

Pepsinogen C (PGC) Monoclonal Antibody

CAU29208-100ul 100ul
EUR 225.6

Pepsinogen C (PGC) Monoclonal Antibody

CAU29208-200ul 200ul
EUR 282.2

Pepsinogen C (PGC) Monoclonal Antibody

CAU29209-100ul 100ul
EUR 242.9

Pepsinogen C (PGC) Monoclonal Antibody

CAU29209-200ul 200ul
EUR 304.1

Pepsinogen A (PGA) Monoclonal Antibody

CAU29499-100ul 100ul
EUR 242.9

Pepsinogen A (PGA) Monoclonal Antibody

CAU29499-200ul 200ul
EUR 304.1

Pepsinogen A (PGA) Monoclonal Antibody

CAU29757-100ul 100ul
EUR 225.6

Pepsinogen A (PGA) Monoclonal Antibody

CAU29757-200ul 200ul
EUR 282.2

Monoclonal Antibody to Pepsinogen A (PGA)

MAA165Hu21 100ul
EUR 253

Monoclonal Antibody to Pepsinogen A (PGA)

MAA165Hu22 100ul
EUR 235

Monoclonal Antibody to Pepsinogen A (PGA)

MAA165Hu23 100ul
EUR 252

Monoclonal Antibody to Pepsinogen A (PGA)

MAA165Hu24 100ul
EUR 243

Monoclonal Antibody to Pepsinogen A (PGA)

MAA165Hu25 100ul
EUR 243

Monoclonal Antibody to Pepsinogen A (PGA)

MAA165Hu26 100ul
EUR 239

Monoclonal Antibody to Pepsinogen A (PGA)

MAA165Hu27 100ul
EUR 243

Monoclonal Antibody to Pepsinogen A (PGA)

MAA165Hu28 100ul
EUR 239

Monoclonal Antibody to Pepsinogen A (PGA)

MAA165Hu29 100ul
EUR 243

Monoclonal Antibody to Pepsinogen C (PGC)

MAA166Hu22 100ul
EUR 235

Monoclonal Antibody to Pepsinogen C (PGC)

MAA166Ra22 100ul
EUR 253

Monoclonal Antibody to Pepsinogen C (PGC)

MBS2012649-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Pepsinogen C (PGC)

MBS2025678-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Pepsinogen A (PGA)

MBS2025737-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Pepsinogen A (PGA)

MBS2090660-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Pepsinogen A (PGA)

MBS2085826-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Pepsinogen A (PGA)

MBS2138440-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Pepsinogen A (PGA)

MBS2138441-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Pepsinogen A (PGA)

MBS2138442-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Pepsinogen A (PGA)

MBS2138443-INQUIRE INQUIRE Ask for price

Pepsinogen A (PGA) Monoclonal Antibody (Pig)

4-MAA165Hu21
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA)

Pepsinogen A (PGA) Monoclonal Antibody (Rat)

4-MAA165Ra21
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA)

Pepsinogen C (PGC) Monoclonal Antibody (Rat)

4-MAA166Ra22
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC)

Pepsinogen A (PGA) Monoclonal Antibody (Human)

4-MAA165Hu22
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA)

Pepsinogen C (PGC) Monoclonal Antibody (Human)

4-MAA166Hu22
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC)

Pepsinogen A (PGA) Monoclonal Antibody (Pig), PE

4-MAA165Hu21-PE
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with PE.

Pepsinogen A (PGA) Monoclonal Antibody (Rat), PE

4-MAA165Ra21-PE
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with PE.

Pepsinogen C (PGC) Monoclonal Antibody (Rat), PE

4-MAA166Ra22-PE
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with PE.

Pepsinogen A (PGA) Monoclonal Antibody (Pig), APC

4-MAA165Hu21-APC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with APC.

Pepsinogen A (PGA) Monoclonal Antibody (Pig), Cy3

4-MAA165Hu21-Cy3
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with Cy3.

Pepsinogen A (PGA) Monoclonal Antibody (Pig), HRP

4-MAA165Hu21-HRP
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with HRP.

Pepsinogen A (PGA) Monoclonal Antibody (Rat), APC

4-MAA165Ra21-APC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with APC.

Pepsinogen A (PGA) Monoclonal Antibody (Rat), Cy3

4-MAA165Ra21-Cy3
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with Cy3.

Pepsinogen A (PGA) Monoclonal Antibody (Rat), HRP

4-MAA165Ra21-HRP
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with HRP.

Pepsinogen C (PGC) Monoclonal Antibody (Rat), APC

4-MAA166Ra22-APC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with APC.

Pepsinogen C (PGC) Monoclonal Antibody (Rat), Cy3

4-MAA166Ra22-Cy3
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with Cy3.

Pepsinogen C (PGC) Monoclonal Antibody (Rat), HRP

4-MAA166Ra22-HRP
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with HRP.

Pepsinogen A (PGA) Monoclonal Antibody (Pig), FITC

4-MAA165Hu21-FITC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Pig Pepsinogen A (PGA). This antibody is labeled with FITC.

Pepsinogen A (PGA) Monoclonal Antibody (Human), PE

4-MAA165Hu22-PE
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with PE.

Pepsinogen A (PGA) Monoclonal Antibody (Rat), FITC

4-MAA165Ra21-FITC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Pepsinogen A (PGA). This antibody is labeled with FITC.

Pepsinogen C (PGC) Monoclonal Antibody (Human), PE

4-MAA166Hu22-PE
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with PE.

Pepsinogen C (PGC) Monoclonal Antibody (Rat), FITC

4-MAA166Ra22-FITC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rat Pepsinogen C (PGC). This antibody is labeled with FITC.

Pepsinogen A (PGA) Monoclonal Antibody (Human), APC

4-MAA165Hu22-APC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with APC.

Pepsinogen A (PGA) Monoclonal Antibody (Human), Cy3

4-MAA165Hu22-Cy3
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with Cy3.

Pepsinogen A (PGA) Monoclonal Antibody (Human), HRP

4-MAA165Hu22-HRP
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsinogen A (PGA). This antibody is labeled with HRP.

Pepsinogen C (PGC) Monoclonal Antibody (Human), APC

4-MAA166Hu22-APC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with APC.

Pepsinogen C (PGC) Monoclonal Antibody (Human), Cy3

4-MAA166Hu22-Cy3
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with Cy3.

Pepsinogen C (PGC) Monoclonal Antibody (Human), HRP

4-MAA166Hu22-HRP
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Pepsinogen C (PGC). This antibody is labeled with HRP.

Pepsin (PP) Antibody

20-abx100019
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Pepsin (PP) Antibody

20-abx100020
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Pepsin (PP) Antibody

20-abx132317
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Pepsin (PP) Antibody

20-abx177932
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Pepsin (PP) Antibody

20-abx177933
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Pepsin (PP) Antibody

20-abx177934
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

 

Formulating monoclonal antibodies as powders for reconstitution at excessive focus utilizing spray-drying: Trehalose/amino acid mixtures as reconstitution time lowering and stability enhancing formulations

 

 

  • To extend their stability, therapeutic (or monoclonal) antibodies (mAbs) are sometimes formulated as solids by utilizing quite a lot of drying strategies, e.g. freeze-drying, spray-drying, or spray freeze-drying. The addition of excipients is required to protect stability of the protein through the drying course of and subsequent storage of the ensuing strong type.

 

  • The addition of low molecular weight excipients, corresponding to amino acids, to sugar primarily based spray- and freeze-dried formulations has been steered to enhance the storage stability of proteins within the dried state.

 

  • On this research sugars (sucrose, trehalose), amino acids (Gly, Ala, Professional, Ser, Val, Leu, Ile, Gln, His, Lys, Arg, Phe, Trp) and mixtures thereof had been investigated for his or her stabilizing impact throughout spray-drying and subsequent storage and for his or her reconstitution time lowering impact. Two IgG4 mAbs had been used as mannequin antibodies.

 

  • From an preliminary screening research, primary and small impartial amino acids, together with a sugar, corresponding to sucrose or trehalose, confirmed reconstitution time lowering and stabilizing properties. Arg specifically displayed glorious reconstitution and stability enhancing properties. Furthermore, Arg was the one amino acid offering stabilizing properties corresponding to sucrose or trehalose.

 

  • Earlier work by the authors described a statistically substantiated comparability between the three primary amino acids in a sugar containing formulation, albeit restricted to a single focus degree [5]. Due to this fact, a follow-up design of experiments (DoE) research was carried out to find out the optimum trehalose/amino acid content material required for an optimum protein stability and reconstitution time and to match the consequences of two primary amino acids, Lys and Arg, to these of two impartial amino acids, Gly and Professional. The performed DoE coated a variety of trehalose (30 – 120 mM) and amino acid (50 – 150 mM)

 

  • The focus of trehalose was discovered to be the principle contributor to a discount in reconstitution time and a rise in stability. Right here we present that the addition of amino acids corresponding to Gly, Professional, and Lys doesn’t enhance stability nor does it scale back the reconstitution time. Of the examined amino acids, solely Arg confirmed a marked discount in reconstitution time and enchancment in stability in comparison with a trehalose.

 

  • Furthermore, the properties displayed by Arg may justify its software as the principle stabilizer in spray-dried mAb formulations, eliminating the necessity for a sugar matrix altogether. However the weight ratio of stabilizer to protein was discovered the issue exerting the strongest total affect on the formulation’s reconstitution time and stability. Extra particularly, ample bodily stability and a suitable reconstitution time could possibly be obtained with a protein to stabilizer weight ratio of a minimum of 1:1.

 

Analysis of two level of care applied sciences for measuring monoclonal antibody therapeutic-A concentrations in blood

Intention: Present blood monitoring strategies require pattern assortment and testing at a central lab, which might take days. Level of care (POC) units with fast turnaround time can present an alternate with quicker outcomes, permitting for real-time knowledge main to raised remedy choices for sufferers.

Outcomes/Methodology: An assay to measure monoclonal antibody therapeutic-A was developed on two POC units. Knowledge generated utilizing 75 serum samples (65 scientific & ten spiked samples) present correlative outcomes to the information generated utilizing Gyrolab know-how.

Conclusion: This case research makes use of a monoclonal antibody therapeutic-A focus assay for instance to display the potential of POC applied sciences as a viable various to central lab testing with fast outcomes permitting for real-time decision-making.

 

PON1 mouse monoclonal antibody, clone OTI2A6 (formerly 2A6)

TA502610 100 µl Ask for price

PON1 mouse monoclonal antibody, clone OTI2A6 (formerly 2A6)

TA502610S 30 µl Ask for price

PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7)

TA502611 100 µl Ask for price

PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7)

TA502611S 30 µl Ask for price

PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9)

TA502612 100 µl Ask for price

PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9)

TA502612S 30 µl Ask for price

Monoclonal PON1 Antibody, Clone: 4G8D3

AMR09437G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PON1. The antibodies are raised in Mouse and are from clone 4G8D3. This antibody is applicable in WB and IHC, FC, ICC, E

Rabbit Anti Human PON1 Monoclonal Clone ACAG-16

IRBAHUPON1ACAG16C100UL each
EUR 496
Description: Rabbit Anti Human PON1 Monoclonal Clone ACAG-16

Monoclonal PON1 Antibody, Clone: 4G8A12

AMM02955G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PON1. The antibodies are raised in Mouse and are from clone 4G8A12. This antibody is applicable in WB and IHC, FC, E

Monoclonal Antibody to Paraoxonase 1 (PON1)

MAA243Ra21 100ul
EUR 253

PON1 Mouse Monoclonal Antibody

E10-30571 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI1F7

TA600112 100 µg Ask for price

PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI2A6

TA600113 100 µg Ask for price

PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI2D4

TA600114 100 µg Ask for price

Anti-PON1 Mouse Monoclonal Antibody [Clone ID: OTI1F7]

M00516-4 100ul
EUR 523
Description: Boster Bio PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7). Catalog# M00516-4. Tested in ELISA, FC, IHC, WB. This antibody reacts with Human.

Anti-PON1 Mouse Monoclonal Antibody [Clone ID: OTI2D4]

M00516-5 100ul
EUR 523
Description: Boster Bio PON1 mouse monoclonal antibody, clone OTI2D4 (formerly 2D4). Catalog# M00516-5. Tested in ELISA, FC, IF, IHC, WB. This antibody reacts with Human.

Mouse Monoclonal Antibody to PON1

E10-30571A 100ul
EUR 225
Description: Available in various conjugation types.

Mouse Monoclonal Antibody to PON1

E10-30572 100ul
EUR 225
Description: Available in various conjugation types.

Mouse Monoclonal Antibody to PON1

sAP-0865 50ug
EUR 270

Mouse Monoclonal Antibody to PON1

sAP-0866 50ug
EUR 270

Mouse Monoclonal Antibody to PON1

MBS8527855-01mL 0.1mL
EUR 305

Mouse Monoclonal Antibody to PON1

MBS8527855-01mLAF405L 0.1mL(AF405L)
EUR 565

Mouse Monoclonal Antibody to PON1

MBS8527855-01mLAF405S 0.1mL(AF405S)
EUR 565

Mouse Monoclonal Antibody to PON1

MBS8527855-01mLAF610 0.1mL(AF610)
EUR 565

Mouse Monoclonal Antibody to PON1

MBS8527855-01mLAF635 0.1mL(AF635)
EUR 565

Mouse Monoclonal Antibody to PON1

MBS8527856-01mL 0.1mL
EUR 305

Mouse Monoclonal Antibody to PON1

MBS8527856-01mLAF405L 0.1mL(AF405L)
EUR 565

Mouse Monoclonal Antibody to PON1

MBS8527856-01mLAF405S 0.1mL(AF405S)
EUR 565

Mouse Monoclonal Antibody to PON1

MBS8527856-01mLAF610 0.1mL(AF610)
EUR 565

Mouse Monoclonal Antibody to PON1

MBS8527856-01mLAF635 0.1mL(AF635)
EUR 565

Mouse Monoclonal PON1 Antibody (4G8D3)

TA336952 100 µl Ask for price

Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2D4 (formerly 2D4)

CF502528 100 µg Ask for price

Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2A6 (formerly 2A6)

CF502610 100 µg Ask for price

Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7)

CF502611 100 µg Ask for price

Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9)

CF502612 100 µg Ask for price

PON3 mouse monoclonal antibody,clone OTI1A5

TA807382 100 µl Ask for price

PON3 mouse monoclonal antibody,clone OTI1A5

TA807382S 30 µl Ask for price

PON3 mouse monoclonal antibody,clone OTI1B12

TA807383 100 µl Ask for price

PON3 mouse monoclonal antibody,clone OTI1B12

TA807383S 30 µl Ask for price

Mouse Anti-HCMV gH Monoclonal Antibody, clone MAb 5

CABT-NS1153 200 μg
EUR 830
Description: Mouse

PON1 biotinylated detection antibody, ELISA and Luminex validated mouse monoclonal antibody, clone OTI2A6

TA700112 50 µg Ask for price

PON1 biotinylated detection antibody, ELISA and Luminex validated mouse monoclonal antibody, clone OTI2D4

TA700114 50 µg Ask for price

Mouse Anti-Ara h1 IgE Monoclonal Antibody (mAb), Clone 2G11G7

7153 1 mg/ml x 0.1 ml
EUR 246
Description: Allergy

Mouse Anti-Ara h1 IgM Monoclonal Antibody (mAb), Clone 3A1E11

7154 1 mg/ml x 0.1 ml
EUR 246
Description: Allergy

Mouse Monoclonal Anti-Mouse CD160 mAb, PE, (clone CNX46-3), (mouse IgG2bk)

MCD160-PE 50 tests
EUR 416.4

CD20 (MS4A1) mouse monoclonal antibody, clone mAb 75

DDX0110P-100 100 µg Ask for price

KIR2DL4 mouse monoclonal antibody, clone mAb#33, PE

AM26033RP-N 100 Tests Ask for price

Mouse Monoclonal Anti-Mouse CD160 mAb, FITC, (clone CNX46-3), (mouse IgG2bk)

MCD160-F 50 Tests
EUR 489.6

KIR2DL4 mouse monoclonal antibody, clone mAb#33, APC

AM26033AC-N 100 Tests Ask for price

Mouse Monoclonal Anti-Mouse CD160 mAb, Biotin, (clone CNX46-3), (mouse IgG2bk)

MCD160-B 100 tests
EUR 562.8

PON3 mouse monoclonal antibody, clone OTI4H9 (formerly 4H9)

TA807380 100 µl Ask for price

PON3 mouse monoclonal antibody, clone OTI4H9 (formerly 4H9)

TA807380S 30 µl Ask for price

PON3 mouse monoclonal antibody, clone OTI5C3 (formerly 5C3)

TA807381 100 µl Ask for price

PON3 mouse monoclonal antibody, clone OTI5C3 (formerly 5C3)

TA807381S 30 µl Ask for price

PON3 mouse monoclonal antibody, clone OTI5B5 (formerly 5B5)

TA807428 100 µl Ask for price

PON3 mouse monoclonal antibody, clone OTI5B5 (formerly 5B5)

TA807428S 30 µl Ask for price

Mouse Monoclonal Anti-Mouse CD160 mAb, Purified, (clone CNX46-3), (mouse IgG2bk)

MCD160-M 100 ug
EUR 578.4

PON3 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12)

TA807353 100 µl Ask for price

PON3 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12)

TA807353S 30 µl Ask for price

Mouse Anti Mouse BDNF Monoclonal Clone

IMSAMLBDNFC120UL each
EUR 341
Description: Mouse Anti Mouse BDNF Monoclonal Clone

Mouse Anti Mouse BDNF Monoclonal Clone

MBS8421710-INQUIRE INQUIRE Ask for price

Mouse Anti-Mouse Myeloperoxidase (MPO) IgM Monoclonal Antibody (mAb), Clone 8B3A6

7160 1 mg/ml x 0.1 ml
EUR 246
Description: Inflammation

Mouse Anti-Mouse Myeloperoxidase (MPO) IgG3 Monoclonal Antibody (mAb), Clone 3B6A10

7159 1 mg/ml x 0.1 ml
EUR 246
Description: Inflammation

KIR2DL4 mouse monoclonal antibody, clone mAb#33, Aff - Purified

AM26033PU-N 100 µg Ask for price

Ferritin mouse monoclonal antibody, clone mAb 44, Aff - Purified

AM26062PU-N 200 µg Ask for price

Mouse Anti Mouse TH Monoclonal Clone 5B7D10

IMSAMLTH5B7D10C120UL each
EUR 282
Description: Mouse Anti Mouse TH Monoclonal Clone 5B7D10

Mouse Anti Mouse TH Monoclonal Clone 5B7D10

MBS8421747-INQUIRE INQUIRE Ask for price

Mouse Anti Mouse GFAP Monoclonal Clone 3H1

IMSAMLGFAP3H1C120UL each
EUR 260
Description: Mouse Anti Mouse GFAP Monoclonal Clone 3H1

Mouse Anti Mouse GFAP Monoclonal Clone 3H1

MBS8421725-INQUIRE INQUIRE Ask for price

Rabbit Anti-Human PON1 Monoclonal Antibody

CABT-36017RH 100ug
EUR 1008

Monoclonal Functional BAFF-R (mouse) Antibody, mAb , Clone: 9B9

APR16043G 0.1mg
EUR 633.6
Description: A Monoclonal antibody against Human Functional BAFF-R (mouse), mAb . The antibodies are raised in Purified From Concentrated Hybridoma Tissue Culture Supernatant. and are from clone 9B9. This antibody is applicable in FC

Mouse Anti Mouse tPA Monoclonal Clone H27B6

IMSAMSTPAH27B6C1MG each
EUR 595
Description: Mouse Anti Mouse tPA Monoclonal Clone H27B6

ELISA andLuminex validated biotinylated detection antibody PON1 ELISA and Luminex validated mouse monoclonal antibody, clone OTI1F7

TA700113 50 µg Ask for price

Mouse monoclonal Anti-MOZ Clone 127A

TA353278L 500 µg Ask for price

Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7

IMSAMLAIF15G4E7C120UL each
EUR 282
Description: Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7

Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7

MBS8421709-INQUIRE INQUIRE Ask for price

Mouse Anti-D. pteronyssinus Der p2 IgM Monoclonal Antibody (mAb), Clone 2D2B12

7157 1 mg/ml x 0.1 ml
EUR 246
Description: Allergy

Mouse Anti-D. pteronyssinus Der p1 IgG3 Monoclonal Antibody (mAb), Clone 3H4E1

7158 1 mg/ml x 0.1 ml
EUR 246
Description: Allergy

Mouse monoclonal Anti-BCL10 Clone 151

TA352997L 500 µg Ask for price

Mouse monoclonal Anti-CDX1 Clone 123a

TA353093L 500 µg Ask for price

Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1

IMSAMLGFAP2B12F1C120UL each
EUR 282
Description: Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1

Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9

IMSAMLPPARG6D7B9C120UL each
EUR 248
Description: Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9

Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1

MBS8421724-INQUIRE INQUIRE Ask for price

Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9

MBS8421743-INQUIRE INQUIRE Ask for price

Mouse Anti-D. pteronyssinus Der p2 IgG2a Monoclonal Antibody (mAb), Clone 3H8D12

7155 1 mg/ml x 0.1 ml
EUR 246
Description: Allergy

Mouse Anti-D. pteronyssinus Der p2 IgG2b Monoclonal Antibody (mAb), Clone 4C10H3

7156 1 mg/ml x 0.1 ml
EUR 246
Description: Allergy

Mouse monoclonal Anti-Mos Clone S3.1

TA353341L 500 µg Ask for price

Mouse Anti Human TUBB3 Monoclonal Clone

IMSAMLTUBB3C120UL each
EUR 341
Description: Mouse Anti Human TUBB3 Monoclonal Clone

Mouse Anti Human TUBB3 Monoclonal Clone

MBS8421752-INQUIRE INQUIRE Ask for price

Mouse monoclonal Anti-EMA Clone E29

TA352816L 500 µg Ask for price

Mouse monoclonal Anti-CR1 Clone To5

TA353107L 500 µg Ask for price

Mouse monoclonal Anti-p63 Clone BU5

TA353532L 500 µg Ask for price

Mouse monoclonal Anti-XPA Clone 5A2

TA353547L 500 µg Ask for price

Lipoprotein lipase (LPL) mouse monoclonal antibody, clone Mab-7, Purified

BM5512 50 µg Ask for price

Mouse monoclonal Anti-FCGR1 Clone 10.1

TA352787L 500 µg Ask for price

Mouse monoclonal Anti-p13 Clone AA10.2

TA352924L 500 µg Ask for price

Mouse monoclonal Anti-ANO5 Clone 5F7

TA352973L 500 µg Ask for price

Mouse monoclonal Anti-CD68 Clone KP1

TA353054L 500 µg Ask for price

Mouse monoclonal Anti-Cdk1 Clone 3E1.1

TA353088L 500 µg Ask for price

Mouse monoclonal Anti-Cdk2 Clone AN4.3

TA353089L 500 µg Ask for price

Mouse monoclonal Anti-CD29 Clone 8E3

TA353270L 500 µg Ask for price

Mouse monoclonal Anti-MMP1 Clone 3B6

TA353335L 500 µg Ask for price

Mouse monoclonal Anti-MMP2 Clone 4D3

TA353336L 500 µg Ask for price

Mouse monoclonal Anti-MMP3 Clone 1B4

TA353337L 500 µg Ask for price

Mouse monoclonal Anti-MMP9 Clone 2C3

TA353338L 500 µg Ask for price

Mouse monoclonal Anti-MUC1 Clone SM3

TA353346L 500 µg Ask for price

Mouse monoclonal Anti-Plx Clone AZ34

TA353386L 500 µg Ask for price

Mouse monoclonal Anti-Plx Clone AZ44

TA353387L 500 µg Ask for price

PON1 Rabbit Monoclonal Antibody

E10G21865 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Mouse monoclonal Anti-APC11 Clone AX2.1

TA352969L 500 µg Ask for price

Mouse monoclonal Anti-APC4 Clone CIV1.1

TA352971L 500 µg Ask for price

Mouse monoclonal Anti-CD19 Clone BU12

TA353028L 500 µg Ask for price

Mouse monoclonal Anti-CD1c Clone M241

TA353030L 500 µg Ask for price

Mouse monoclonal Anti-CD22 Clone To15

TA353036L 500 µg Ask for price

Mouse monoclonal Anti-CD44 Clone P2A1

TA353042L 500 µg Ask for price

Mouse monoclonal Anti-CD44 Clone BU52

TA353043L 500 µg Ask for price

Mouse monoclonal Anti-CD70 Clone BU69

TA353057L 500 µg Ask for price

Mouse monoclonal Anti-CD72 Clone BU40

TA353059L 500 µg Ask for price

Mouse monoclonal Anti-CD86 Clone BU63

TA353067L 500 µg Ask for price

Mouse monoclonal Anti-Leu2 Clone X107

TA353072L 500 µg Ask for price

Mouse monoclonal Anti-Leu2 Clone BU88

TA353073L 500 µg Ask for price

Mouse monoclonal Anti-Cdk2 Clone AN21.2

TA353090L 500 µg Ask for price

Mouse monoclonal Anti-BORIS Clone 4A7

TA353114L 500 µg Ask for price

Mouse monoclonal Anti-CYP2C6 Clone K1

TA353125L 500 µg Ask for price

Mouse monoclonal Anti-CYP3A1 Clone P6

TA353132L 500 µg Ask for price

Mouse monoclonal Anti-NSE Clone NSEP1

TA353161L 500 µg Ask for price

Mouse monoclonal Anti-NSE Clone NSEP2

TA353162L 500 µg Ask for price

Mouse monoclonal Anti-FGF3 Clone MSD1

TA353194L 500 µg Ask for price

Mouse monoclonal Anti-LewisX Clone 28

TA353199L 500 µg Ask for price

Mouse monoclonal Anti-INFa Clone ST29

TA353240L 500 µg Ask for price

Mouse monoclonal Anti-PCNA Clone PC10

TA353373L 500 µg Ask for price

Mouse monoclonal Anti-Cdc20 Clone BA8

TA353388L 500 µg Ask for price

Mouse monoclonal Anti-PSMA5 Clone AH1.1

TA353401L 500 µg Ask for price

Mouse monoclonal Anti-PTPRC Clone C11

TA353403L 500 µg Ask for price

Mouse monoclonal Anti-LAT1 Clone BU53

TA353464L 500 µg Ask for price

Mouse monoclonal Anti-TIMP1 Clone 2A5

TA353510L 500 µg Ask for price

Mouse monoclonal Anti-TIMP2 Clone 3A4

TA353511L 500 µg Ask for price

Mouse monoclonal Anti-WIPI2 Clone 2A2

TA353546L 500 µg Ask for price

*Mouse Anti Mouse Prekallikrein Monoclonal Clone 5G7

IMSAMSPK5G7C100UG each
EUR 315
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 5G7

*Mouse Anti Mouse Prekallikrein Monoclonal Clone 5G7

IMSAMSPK5G7C1MG each
EUR 2516
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 5G7

*Mouse Anti Mouse Prekallikrein Monoclonal Clone 7G2

IMSAMSPK7G2C100UG each
EUR 315
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 7G2

*Mouse Anti Mouse PAI-1 Monoclonal Clone H14H7

IMSAMSPAI1H14H7C10MG each
EUR 5964
Description: *Mouse Anti Mouse PAI-1 Monoclonal Clone H14H7

*Mouse Anti Mouse PAI-1 Monoclonal Clone H14H7

IMSAMSPAI1H14H7C1MG each
EUR 889
Description: *Mouse Anti Mouse PAI-1 Monoclonal Clone H14H7

Mouse Anti Mouse PAI-1 Monoclonal Clone H34G6

IMSAMSPAI1H34G6C10MG each
EUR 5964
Description: Mouse Anti Mouse PAI-1 Monoclonal Clone H34G6

Mouse Anti Mouse PAI-1 Monoclonal Clone H34G6

IMSAMSPAI1H34G6C1MG each
EUR 889
Description: Mouse Anti Mouse PAI-1 Monoclonal Clone H34G6

Mouse monoclonal Anti-Leu1 Clone Y2/178

TA353051L 500 µg Ask for price

Mouse monoclonal Anti-MHCII Clone BU20

TA352833L 500 µg Ask for price

Mouse monoclonal Anti-Mglu3 Clone 4B92.1

TA352845L 500 µg Ask for price

Mouse monoclonal Anti-BCRABL Clone 7c6

TA352923L 500 µg Ask for price

Mouse monoclonal Anti-ASAP1 Clone 7B12

TA352983L 500 µg Ask for price

Leave a Reply

Your email address will not be published.